The 2025 NephJC Night, in Houston — NephJC SAVE THE DATE! On FRIDAY night, NOVEMBER 7th, NephJC will be hosting another of its legendary NephJC Nights during ASN Kidney Week

The 2025 #NephJC at #KidneyWk details

www.nephjc.com/news/2025/10...

Thanks to @jadav.bsky.social!

A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky

Nailed it.

The list is short and contains none :)

Fascinating that CLYM116 is compared to sibe in a preclinical study. Hope we see more head-to-head comparisons with other leading or emerging agents!

These issues are really important

Lots of KOLs pushing multi target therapy in IgA Nephropathy with basically no data in trails to date

It’s mechanistically appealing but who knows what the right answer is unless we do the studies

Safety and Efficacy of Long-Term Voclosporin Treatment for Lupus Nephritis in the Phase 3 AURORA 2 Clinical Trial - PubMed Data demonstrate the safety and efficacy of long-term voclosporin treatment over three years of follow-up in patients with LN.

And there is the longer term followup study AURORA 2 that did not show signs of nephrotoxicity (concern of course with CNI)

pubmed.ncbi.nlm.nih.gov/37466424/

Very strange post singling out Voclosporin and lupus nephritis from the FDA CDER chap

www.linkedin.com/posts/george... since deleted already

h/t @ericweinhandl.bsky.social and @grahamabra.bsky.social

Agreed.

I’m all for proteinuria reduction to bring in more smart people to kidney disease work but we need to make sure we avoid the never ending phosphate binder style blackhole of believing and writing surrogate outcome altering meds into guidelines

Show me the 📈 GFR!

And it’s live

Iptacopan in C3GN makes it to @thelancet.com

www.thelancet.com/journals/lan...

#NephSky

A 52-year-old woman with hypertension presented to the hospital with a 1-month history of fatigue, as well as 6 days of vomiting and 1 day of confusion. Over the past 20 years, she had not received regular treatment for hypertension. 1/2

#MedSky

Small group Peritoneal Dialysis case discussion leaders at the Home Dialysis Academy of Excellence!

Drs Ananthakrishnan and Young from UC Davis Division of Nephrology Dr @grahamabra.bsky.social from Stanford Division of Nephrology and Dr Harini Sarathy from UCSF Division of Nephrology

NephJC 2025 Fall Pledge Drive — NephJC Help keep NephJC a vital, original, and unbiased source of medical education.

It's that time of year again 🍂🍂🍂
The #NephJC Fall pledge drive.
Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

I teach it. I have not seen this studied in a systematic way, but Edelman equation is not just a good idea, it’s the law.

Has anyone studied the use of K supplementation to increase daily solute load and subsequently free water excretion in SIADH?

#AskRenal

Certainly warrants more investigation, understudied area, we need good prospective RCTs targeting CGM metrics and/or HbA1c in ESKD showing improvement in important clinical outcomes (DM complications, hospitalizations ect) to know

🤦‍♂️

A new era of lupus nephritis therapy is here Lupus nephritis occurs in approximately half of patients diagnosed with systemic lupus erythematosus. One in 10 patients with lupus nephritis will progress to end-stage kidney disease, and risk is hig...

It’s an exciting time to be taking care of patients with Lupus Nephritis!

www.healio.com/news/nephrol...

Calling @hswapnil.medsky.social

🚨 vitamin D alert 🚨

Glycemia Assessed by Continuous Glucose Monitoring among... : Journal of the American Society of Nephrology ilure and its treatments disrupt glucose homeostasis in ways that may promote both hyperglycemia and hypoglycemia. Continuous glucose monitoring (CGM) delineates detailed glycemic profiles, but publis...

Here’s the link to the paper - original post has the poster

journals.lww.com/jasn/fulltex...

Great question.

Don’t know myself but always been fascinated by the question of why PD and HD mortality outcomes are the same despite being totally different modalities

Do the metabolic complications outweigh the other benefits of PD (eg better kidney function preservation)?

#AskRenal

Huge kudos to Northwest Kidney for making this study possible

This is the kind of pragmatic ESKD research we need

Non-profit reinvesting in the mission!

One of the limitations of drug dosing studies is that they have historically used CrCl, always a bit of guesswork when using other estimates of kidney function

Curious if folks ever use this in setting of rapidly rising creatinine to make med dosing decisions - why or why not?

#AskRenal @askrenal.bsky.social

www.mdcalc.com/calc/10191/k...

The metabolic stress of PD is real!

Check out the mean glucose across the day - that cycler really hits those with treated DM!

The PD (n=55) findings are fascinating

No DM, mean (SD) blood glucose was 121 (16) mg/dl for participants treated with HD and 141 (25) mg/dl for those treated with PD (P < 0.001)

The mean TIR (70–140 mg/dl) was 77% for HD and 55% for PD, w/ most of remaining time spent above range (>140 mg/dl)!

Glycemia Assessed by Continuous Glucose Monitoring among... : Journal of the American Society of Nephrology ilure and its treatments disrupt glucose homeostasis in ways that may promote both hyperglycemia and hypoglycemia. Continuous glucose monitoring (CGM) delineates detailed glycemic profiles, but publis...

Have hyperglycemia (and other DM badness) been hiding in plain sight in ESKD?

Probably.

Great study using CGMs in ESKD.

Pts with treated DM, mean TIR only 43% while mean HbA1c was 7.0%

journals.lww.com/jasn/abstrac...

If you are seeing patients with #ckm (cardiac, kidney, metabolic) syndrome, you should be aiming for (and justifying if you are not) the #RuleOf10: 10mg of each of Ramipril, Empagliflozin, Finerenone, Rosuvastatin, Ezetimibe, Tirzepatide for your patients (or equivalent doses of similar drugs).

A famous nephrologist getting ready to go see the most famous guy who plays a nephrologist @glaucomflecken.bsky.social @stanforddeptmed.bsky.social Grand Rounds!