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Jeff Lee

@jeffylee.bsky.social

RNA Biologist | University of Glasgow

41 Followers  |  59 Following  |  4 Posts  |  Joined: 02.01.2025  |  1.4159

Latest posts by jeffylee.bsky.social on Bluesky

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

03.06.2025 22:01 β€” πŸ‘ 18    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

03.03.2025 15:55 β€” πŸ‘ 114    πŸ” 36    πŸ’¬ 6    πŸ“Œ 2

Thank you, Alfredo! πŸ₯³

18.02.2025 11:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development RNA binding protein combinations control neuronal identity through a network of temporal regulators.

Amazing work of our dear friends @ilandavis.bsky.social and @jeffylee.bsky.social characterising the interlinked roles of two key RBPs in drosophila brain development, congratulations 🍾πŸ₯‚πŸŽ‰πŸŽ‰πŸŽ‰ www.science.org/doi/10.1126/...

17.02.2025 19:02 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development RNA binding protein combinations control neuronal identity through a network of temporal regulators.

Jeff Lee et al paper from my lab is out now
www.science.org/doi/10.1126/...

I am very grateful to Jeff, Nile's and Tamsin for all the hard work on this tour de force paper.
Jeff deserves more credit than me for masterminding it and the outstanding data analysis: 2 RBPs over 3 developmental times.

12.02.2025 23:18 β€” πŸ‘ 35    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0
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Following our recent publication, here’s a striking collage of developing fly brain! 🧠✨ Highlighting the dynamic expression of RNA-binding proteins Imp (green) and Syp (magenta) www.science.org/doi/10.1126/...

10.02.2025 17:42 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Grateful to Niles, Tamsin, @ilandavis.bsky.social, and our amazing collaborators for their support in this journey! πŸ™Œ

10.02.2025 17:31 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial networks of regulators of Drosophila brain development RNA binding protein combinations control neuronal identity through a network of temporal regulators.

πŸ§ πŸ”¬How do RNA-binding proteins shape brain development? Our latest study reveals how Imp & Syp form combinatorial networks to regulate Drosophila neurogenesis. Excited to share this work in #ScienceAdvances!
πŸ“œ Read more: www.science.org/doi/10.1126/... #ilandavislab #RNA #neurogenesis

10.02.2025 17:30 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

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