Pankaj Kapahi

Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...

The war zone in Portland is out of control.

Glycation-lowering compounds curb hunger, lower insulin resistance and extend lifespan in mice Buck scientists fight the sugary chemistry of aging The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. ...

Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social

Had a wonderful time at the Barshop aging Meeting at Banderas!

The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

After months in limbo, four NIH institute directors fired Two leaders removed by Trump administration had hoped to stay at agency as in-house investigators

www.science.org/content/arti...

Congratulations

“How we spend our days is, of course, how we spend our lives.” Annie Dillard

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.

That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.

www.nytimes.com/2025/10/01/o...

Cartoon showing a stick figure looking toward an end goal w/ a bumpy path to it.

Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).

Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...

#neuroskyence

Shutdown Could Leave 750,000 Federal Workers Furloughed The projections, sent to lawmakers on Tuesday, highlight the sweeping consequences of a lapse in federal funding.

time.com/7322026/shut...

thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.

#vss365

The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.

Totally agree! I sent a signed card from all the trainees of our course!

Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping.
buff.ly/kWvdl5i

about the $100K H1B fee, here's some interesting details: "If an employee is in the U.S., he or she will not be subject if (i) applying to extend or amend H-1B status, or (ii) applying to change from another visa category into H-1B status from within the U.S."

How did you find it - would love to go there

Early puberty and early childbirth may come with a cost Reproductive timing can accelerate aging and disease

Early #puberty and early childbirth may come with a cost. Study in @elife.bsky.social shows reproductive timing can accelerate aging and disease, quadrupling the risk of severe metabolic disorders. Congrats @pkapahi.bsky.social www.buckinstitute.org/news/early-p...

Creative frustration

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

RESEARCH | 🧪

S Bar, ‪ @pkapahi.bsky.social et al
@buckinstitute.org

Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster

www.nature.com/articles/s42...

Neurons burn sugar differently. The discovery could save the brain. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.

Neurons burn #sugar differently. The discovery from the Kapahi lab could save the brain. Study in Nature Metabolism
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social

Renewal of NIH grants linked to more innovative results, study finds Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

www.nature.com/articles/d41...

Cannot emphasize this too strongly.

Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV - GeroScience Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to m...

link.springer.com/article/10.1...

Delighted to be part of this collaborative effort

THIS IS HUGE! Researchers at Memorial Sloan Kettering Cancer Center say results of a Phase I trial of an mRNA vaccine aimed at preventing pancreatic cancer show promise. The vaccine PREVENTED the cancer from coming back in patients who had already received treatment for MORE THAN three years. 🧪🧵⬇️

It’s my favorite place in LA

Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4 - Diabetologia Aims/hypothesis Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cerebral metabolism have been proposed as a potential mechanism underly...

Type 2 diabetes alters cerebral blood flood, glucose metabolism, and fatty acid metabolism.

APOE4+ have increased fatty acid metabolism independent of T2D.

link.springer.com/article/10.1...