Pankaj Kapahi

Neurons burn sugar differently. The discovery could save the brain. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.

Neurons burn #sugar differently. The discovery from the Kapahi lab could save the brain. Study in Nature Metabolism
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social

Renewal of NIH grants linked to more innovative results, study finds Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

www.nature.com/articles/d41...

Cannot emphasize this too strongly.

Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV - GeroScience Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to m...

link.springer.com/article/10.1...

Delighted to be part of this collaborative effort

THIS IS HUGE! Researchers at Memorial Sloan Kettering Cancer Center say results of a Phase I trial of an mRNA vaccine aimed at preventing pancreatic cancer show promise. The vaccine PREVENTED the cancer from coming back in patients who had already received treatment for MORE THAN three years. 🧪🧵⬇️

It’s my favorite place in LA

Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4 - Diabetologia Aims/hypothesis Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cerebral metabolism have been proposed as a potential mechanism underly...

Type 2 diabetes alters cerebral blood flood, glucose metabolism, and fatty acid metabolism.

APOE4+ have increased fatty acid metabolism independent of T2D.

link.springer.com/article/10.1...

Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter Opportunity for LSI PHD studentship – starting in September 2025 or January 2026 PhD Studentship applications will open on 1st...

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social.
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...

How Trump is following Project 2025’s radical roadmap to defund science Much of the Trump administration’s agenda for research is laid out in the 900-plus-page blueprint. Nature read it so you don’t have to.

Much of the Trump administration’s agenda for research is laid out in the 900-plus-page Project 2025. Nature examines science-related policies from Project 2025 that have already come to pass, and which ones might be on the horizon. 🧪

I'm so amped by all the positive energy, brilliant creative signs, and seeing so many people across the country #StandUpForScience! Let's use this motivation to stay loudly in this fight. Every small action matters

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse!
Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...

How do you find the gorilla hiding in your data?
The "Postdoc Night Science NYC" club meets for the second time next Thursday to discuss this at NYU. The response so far has been overwhelming but there are probably a few more spots if you can join us!
docs.google.com/forms/d/1Shc...

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field.
Interdisciplinary work is still not really embraced by academia.

PhD students: it’s a waste to just try to impress your committee at the meeting. Bring them problems, ask for suggestions, and generally think of it as a session in which new ideas can emerge.

You are Losing it … how is this going to be entertaining:)

Research involves day science and night science, requiring you to become good at both. Day science proceeds in logical steps and specializes in hypothesis testing, but to generate new ideas we pop out to the creative night science world, where leaps among ideas are made possible.

Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's my strategy for how to prepare for the presentation, actually present it, and then answer the questions.

If you haven't already, make a donation to Wikipedia - help sustain a great resource while pissing off the Nazi who bought the presidency

Just like our papers

1-1 meetings are much more interesting when done alongwith a walk

Only 2 more days to apply for our Early Career Scholars Program! Don't miss out on this great opportunity!

This seems really cool - tell me more - do some aggregates get seeded in the enteric system

Congratulations to all the authors! Should be great for the field - and yes looking forward to the searchable database- thanks for doing that to make it user friendly

Circadian clocks - started with work in the Benzer lab

Now more than ever It is vital that we educate people about how research on model organisms had been fundamental in advancing our understanding of genetics, development, and cell biology, and this discovery driven research is foundational for disease focused studies. Consider these 8 Nobel Prizes:

UC Irvine-co-led study finds DNA damage is key factor in age-related macular degeneration Targeting specific retinal cell types could lead to treatments that slow or stop progression

Thank you @ucirvine.bsky.social for highlighting our work!
news.uci.edu/2024/12/03/u... #agingeye #womeninscience #collaborations

OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇
www.nature.com/articles/s41...
#GeroSky

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...