Pankaj Kapahi

It's clear that most people don't read to learn, to enjoy.

They read to sound smart, appear clever, and tell others they've read so and so "classic" writers.

They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.

Recent discoveries on the acquisition of the highest levels of human performance Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

Multidisciplinary training, over time, produces the highest impact people

www.science.org/doi/10.1126/...

Mapping the genetic landscape across 14 psychiatric disorders - Nature Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

Top #Altmetric 2025: 7️⃣🧪

@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

Postdoctoral Researcher positions-Kapahi lab - Buck Institute - Career Page The Kapahi lab seeks postdocs to lead innovative projects exploring how circadian clocks & nutrient-responsive pathways influence eye & neuronal degeneration.

🚀 Postdoc opportunity!

The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈

👉

The Kapahi Lab is looking for two creative, motivated postdocs to join our team.

We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.

pkapahi@buckinstitute.org

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.

#Throwback 🧪

REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

S Deota, S Panda et al.

Evolution of taste processing shifts dietary preference - Nature Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...

Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...

Cellular and organismal function of choline metabolism - Nature Metabolism Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

#Throwback 🧪

REVIEW | Cellular and organismal function of choline metabolism

M Abu-Remaileh, K Birsoy et al.

Deadline closing soon!

Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.

📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience

Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...

The war zone in Portland is out of control.

Glycation-lowering compounds curb hunger, lower insulin resistance and extend lifespan in mice Buck scientists fight the sugary chemistry of aging The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. ...

Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social

Had a wonderful time at the Barshop aging Meeting at Banderas!

The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

After months in limbo, four NIH institute directors fired Two leaders removed by Trump administration had hoped to stay at agency as in-house investigators

www.science.org/content/arti...

Congratulations

“How we spend our days is, of course, how we spend our lives.” Annie Dillard

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.

That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.

www.nytimes.com/2025/10/01/o...

Cartoon showing a stick figure looking toward an end goal w/ a bumpy path to it.

Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).

Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.

Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...

#neuroskyence

Shutdown Could Leave 750,000 Federal Workers Furloughed The projections, sent to lawmakers on Tuesday, highlight the sweeping consequences of a lapse in federal funding.

time.com/7322026/shut...

thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.

#vss365

The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.

Totally agree! I sent a signed card from all the trainees of our course!

Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping.
buff.ly/kWvdl5i

about the $100K H1B fee, here's some interesting details: "If an employee is in the U.S., he or she will not be subject if (i) applying to extend or amend H-1B status, or (ii) applying to change from another visa category into H-1B status from within the U.S."