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Paul Sauer

@paulsauer.bsky.social

Structural Biologist and outdoor enthusiast

64 Followers  |  37 Following  |  2 Posts  |  Joined: 28.11.2023  |  1.4361

Latest posts by paulsauer.bsky.social on Bluesky

January 29, 2025
M-25-14
MEMORANDUM FOR HEADS OF EXECUTIVE DEPARTMENTS AND AGENCIES
FROM: Matthew J. Vaeth, Acting Director, Office of Management and Budget Me
SUBJECT: Rescission of M-25-13
OMB Memorandum M-25-13 is rescinded. If you have questions about implementing the
President's Executive Orders, please contact your agency General Counsel.

January 29, 2025 M-25-14 MEMORANDUM FOR HEADS OF EXECUTIVE DEPARTMENTS AND AGENCIES FROM: Matthew J. Vaeth, Acting Director, Office of Management and Budget Me SUBJECT: Rescission of M-25-13 OMB Memorandum M-25-13 is rescinded. If you have questions about implementing the President's Executive Orders, please contact your agency General Counsel.

🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs.

Full text, per government source:

29.01.2025 17:48 β€” πŸ‘ 11975    πŸ” 3828    πŸ’¬ 692    πŸ“Œ 1920

Our first paper here at #interdictbio!

22.01.2025 06:43 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. 🧡

21.01.2025 13:24 β€” πŸ‘ 553    πŸ” 57    πŸ’¬ 51    πŸ“Œ 1

"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"

10.01.2025 20:00 β€” πŸ‘ 12    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Preview
Context-dependent translation inhibition as a novel oncology therapeutic modality Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

Is RNA translation the next hot area in #cancer therapeutics?

Take a look and make a decision for yourself!

#RNAsky
#ONCSky
🧬 πŸ’»
#genomics

www.biorxiv.org/content/10.1...

10.01.2025 13:23 β€” πŸ‘ 22    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Congratulations @trinitycookis.bsky.social for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!

10.01.2025 11:30 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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