Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ...

In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

De novo identification of the specificities of recurrent human T cell receptors https://www.biorxiv.org/content/10.1101/2025.08.03.668342v1

Technical blogging for growth and learning Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. This post: why blog, what to blog about, how to start, and using AI.

Writing a technical blog improves your writing, forces you to learn new things, helps others and yourself, and helps your career. In this essay: (1) why blog, (2) what to blog about, (3) how to get started, and (4) using AI. https://doi.org/10.59350/bqnfd-7p249 🧪

Double negative T cells can act as professional APCs capable of tolerance induction? How fascinating - I'm picturing a western stand-off between two T cells (both equipped with granzymes btw) unwilling to let go of the other!

Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...

Autoantibodies against cytokines, growth factors, immunoreceptors, & tumor surface proteins robustly modulate immune checkpoint inhibition therapy response @aaronmring.bsky.social @nature.com
www.nature.com/articles/s41...

the treasure trove of all sequencing datasets

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...

Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

My last history lesson in school was in 2012. Today I realized that my memory is blank on certain events outside biology, many probably. Fx. I had no idea the EU includes illegal activities in calculating GDP. The amount of colorful assumptions as to how much this contributes to GDP must be wild!

Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers @natcomms.nature.com
www.nature.com/articles/s41...

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus Patients with systemic lupus erythematosus exhibit aging-related decreases in interferon signaling that correlate with improved disease activity.

Wow, when lower IFN in aging is a good thing! Congratulations Chaz L and team. #ImmuneProfiling
#Aging Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus | Science Translational Medicine www.science.org/doi/10.1126/...

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!

ChatGPT is fun, but not an author In less than 2 months, the artificial intelligence (AI) program ChatGPT has become a cultural sensation. It is freely accessible through a web portal created by the tool’s developer, OpenAI. The progr...

Outright banning ChatGPT? Like a commenter said, chess robots have been instrumental in teaching chess, so why can't AI be a way to teach better scientific writing? "ChatGPT is fun, but not an author" | Science www.science.org/doi/10.1126/...

A perfect date in Erlangen for me really is June 19th. Summer, green parks, a long weekend ahead, and nobody in sight!

Absolutely fascinating work.

""In this vein, we contend that future incorporation of physiological microbial exposure into animal models may offer translational value to the study of brain health and disease.""

(most? any? some?) Infections create a T cell memory in the brain.

Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes @natimmunol.nature.com
www.nature.com/articles/s41...

Really interesting new study on CD8+ T cells in MS from @ali-syedaliraza.bsky.social and Danny Reich

CSF single-cell RNA sequencing reveals clonally expanded CD4+ stem cell-like memory T cells in GAD65-antibody associated neurological syndromes https://www.biorxiv.org/content/10.1101/2025.05.18.654720v1

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways
www.nature.com/articles/s41...

The blood–brain barrier, chemokines and multiple sclerosis The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the neuropathogenesis of multiple sclerosis (MS). Leukocy…

A reminder to myself that chemokines are likely not exerting their effects via soluble concentration gradients due to their binding to GAGs.

At least they weren't in 2011, when this well written review was made!
www.sciencedirect.com/science/arti...

Mechanism by IL-15 stimulates bystander memory CD8+ T-cells to enter the CNS and contribute to injury independent of antigen-specific stimulation
www.biorxiv.org/content/10.1...

Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...

A functionally validated TCR-pMHC database for TCR specificity model development Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...

It's not the models, it's the data!

We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.

www.biorxiv.org/content/10.1...

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko
See below for details and preprint

Happy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances!

www.science.org/doi/10.1126/...

Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab

Your immune system gradually loses it top team players when we get older 👱➡️👵
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR

Day 1 of (re-)discovering shortcuts on computers.

You can rename files in windows by pressing F2.

We are still #hiring! We are looking for researchers to lead studies on human B cells and plasma cells.

Please use this Emory link to apply: shorturl.at/MaO5d