Yann Moalic

Substrate specificity and action mechanism of the HerA-NurA nuclease from the hyperthermophilic archaeon Thermococcus kodakarensis | mBio To understand the specific function of the HerA-NurA complex, which is believed to function in the end resection process to create a 3′-overhanging DNA for the following strand invasion in homologous ...

journals.asm.org/doi/10.1128/...

Evolution and diversity of oxidoreductases involved in redox balance and energy conservation - Nature Ecology & Evolution HORBEC are protein complexes involved in the regulation of redox balance and energy conservation. The authors develop a bioinformatic tool for HORBEC annotation in bacterial and archaeal genomes and r...

www.nature.com/articles/s41...

Bipartite network of ncORF-CDS co-translation in mice

🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/6TsX3ct

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life Abstract. Archaea, a domain of microorganisms found in diverse environments, including the human microbiome, represent the closest known prokaryotic relati

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life url: academic.oup.com/nar/article/...

A web-based atlas for exploring post-transcriptional regulation in the archaeon Sulfolobus acidocaldarius | mSystems Post‑transcriptional regulation is a key control layer in gene expression. Yet, resources integrating antisense RNAs (asRNAs), RNA processing sites, and RNA-protein interactions are scarce for archaea...

A web-based atlas for exploring post-transcriptional regulation in the archaeon Sulfolobus acidocaldarius
#microbiology #archaea #MicroSky #ArchaeaSky
@asm.org
journals.asm.org/doi/10.1128/...

Iron Sulfides Produced by Thermococcales: An Iron Detoxification Mechanism Thermococcales, archaea from hydrothermal vents, promote iron sulfide precipitation, enabling survival in iron-rich environments. Some cells become encrusted in pyrite and do not survive mineralizati...

enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

www.nature.com/articles/s41...

How the ocean’s hydrothermal systems made the first life on Earth possible Researchers have discovered that chemical reactions in underwater hydrothermal vents could have produced the necessary ingredients for life on Earth.

How the ocean’s hydrothermal systems made the first life on Earth possible

Predicting protein interfaces in the age of AlphaFold: Why dynamics and disorder remain a challenge Two recent studies in Cell Systems show why protein dynamics matter for prediction. By moving beyond static structures and embracing the dynamic “jigglings and wigglings” that Richard Feynman famously...

www.cell.com/cell-systems...

Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2 Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p

academic.oup.com/nar/article/...

New preprint from my lab (with Arya Kaul, @fernpizza.bsky.social, and @brinda.eu), in which we explore new genes hitchhiking on the beneficial deletion that fused them together, and find them in the LTEE, M. Tb/bovis, and across the bacterial tree of life

Now published in Nature Biotechnology:
go.nature.com/44P7nSm
If you missed it, the TL;DR is in my April thread below

Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading - Nature Communications DNA damage can lead to cell death. Here, the authors show that a simple cut on either strand of DNA can inactivate bacterial chromosome replication. Surprisingly, only a core set of recombination prot...

A cool genetic system to study site-pecific replication fork collapse and repair from the brilliant @winterhalterlab.bsky.social

www.nature.com/articles/s41...

Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

FYI: New online! Detecting transcription factor binding sites with PADIT-seq

Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota) Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways1–3. Asgard archaea (phylum Promethearchae...

1. As we recently joined BlueSky, we want to repost this story for all newcomers!

We sat down with @radler92.bsky.social to get more insight into the unique videos from his recent preprint on Promethearchaeota (formerly Asgard archaea).

doi.org/10.1101/2025...

(Videos and info below)

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...

So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?

Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.

Sign up: meetings.embo.org/event/26-arc...

We look forward to seeing you in Cambridge, UK.

Please repost!

The emergence of eukaryotes as an evolutionary algorithmic phase transition | PNAS The origin of eukaryotes represents one of the most significant events in evolution since it allowed the posterior emergence of multicellular organ...

www.pnas.org/doi/10.1073/...

🚨 What if evolution is the ”law”… and networks are the machines that do the work?

In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠

👉 iopscience.iop.org/article/10.1...

🧵 1/

A web-based atlas for exploring post-transcriptional regulation in the archaeon Sulfolobus acidocaldarius | mSystems Post‑transcriptional regulation is a key control layer in gene expression. Yet, resources integrating antisense RNAs (asRNAs), RNA processing sites, and RNA-protein interactions are scarce for archaea...

journals.asm.org/doi/10.1128/...

Scikit-bio: a fundamental Python library for biological omic data analysis - Nature Methods Nature Methods - Scikit-bio: a fundamental Python library for biological omic data analysis

The scikit-bio paper in online in Nature Methods! Many thanks to our collaborators, community contributors and reviewers! We couldn’t have done it without you. www.nature.com/articles/s41... #Bioinformatics #OpenSource

academic.oup.com/bib/article/...

Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states thro...

Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!

www.pnas.org/doi/10.1073/...

Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Nature research paper: Ribonucleotide incorporation into mitochondrial DNA drives inflammation

go.nature.com/3KBRg2W

Unlocking the genome's hidden half with new DNA sequencing technology Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome.

A high-resolution genome mapping technique now enables detailed study of transposons, offering new insights into genetic evolution, disease mechanisms, and potential agricultural advancements. doi.org/hbb5vk

How Genes Express Themselves - Lasker Foundation Robert Roeder was starting to worry in early 1969. A graduate student at the University of Washington, he’d been working long hours in the lab and filling notebook after notebook with data, but he…

How do cells activate or silence genes? Read about the #LaskerAward winners who devised ingenious experimental methods, leveraged offbeat model organisms, & capitalized on underappreciated observations to understand how organisms carefully control gene activity.
#LaskerLaureate 🧪

To reform universities, first tackle global rankings Universities are in thrall to a rankings system that prioritizes narrow aspects of academic life. Three changes would give institutions the freedom to explore fresh ways of working.

Academia is plagued by not-fit-for-purpose metrics that are then used ranking individuals and institutions
Will we ever move away from these? - there is a lot of talk but not a great deal of action?
The comment ⬇️ is a refreshing look at the problem.
www.nature.com/articles/d41...

IA : Blaise Agüera y Arcas, le chercheur de Google qui s’interroge sur la conscience des machines Chercheur et vice-président du géant américain de la tech, Blaise Agüera y Arcas publie un ouvrage dans lequel il soulève la question qui agite la Silicon Valley : la conscience est-elle le propre des...

www.lemonde.fr/economie/art...