Yann Moalic

Viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts reveal intricate nested interactions - Nature Microbiology An exploration of the viromes of haloarchaea and their ultra-small DPANN symbionts reveals plasmid-derived satellites of viruses from both archaeal groups, highlighting the complexity of nested symbio...

www.nature.com/articles/s41...

www.ignotalabs.ai/news/if-you-...

The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology The exploration of life in extreme environments gained prominence with Thomas Brock’s “Life at High Temperatures” (1), and his subsequent isolation of Thermus aquaticus with Hudson Freeze in 1969 (2) ...

The Thermococcales as a model system: historical perspectives and emerging tools | Journal of Bacteriology journals.asm.org/doi/10.1128/...

Methanobrevibacter smithii Methanobrevibacter smithii is one of the most prevalent and worldwide distributed archaea in the human gut. M. smithii is a strict anaerobe that obtains its energy through methanogenesis. In culture, ...

Methanobrevibacter smithii: Trends in Microbiology www.cell.com/trends/micro...

PhD training needs a reboot in an AI world As machines get better at data analysis and writing tasks, doctoral training must evolve to make the most of artificial-intelligence outputs.

AI is not just another research tool; it is redefining what research is, how it is done and what counts as an original contribution

go.nature.com/47Uh6sf

Phage G genome: AI analysis maps out world's largest cultivated bacteria-killing virus Through cutting-edge methods and advanced artificial intelligence analysis, UNC Charlotte researchers leading a multidisciplinary team across four universities have successfully resolved the entire genome of "Phage G," the largest bacterial virus (aka bacteriophages or phages) ever cultivated in a physical lab environment.

Artificial intelligence has enabled the complete mapping of Phage G, the largest cultivated bacteriophage, providing a new model for studying megaphages and potential antimicrobial applications. doi.org/g98g28

Big pharma seduced by transcription factors again. What has changed? - Nature Biotechnology Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play ...

Big pharma seduced by transcription factors again. What has changed? www.nature.com/articles/s41...

Cross-species “xenotransplants”, as the well-worn joke goes, are the future—and always will be. But that punchline is starting to sound out of touch econ.st/4qvPMIf

Illustration: Allie Sullberg

One transcript, two functions: the emerging roles of dual-function RNAs Abstract. Bacteria use small regulatory RNAs (sRNAs) and small proteins to change gene expression and modulate cellular processes in response to changing e

One transcript, two functions: the emerging roles of dual-function RNAs

microLIFE review by @lizmarialuke.bsky.social and Kai Papenfort at @uni-jena.de

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Human genetic structure in Northwest France provides new insights into West European historical demography - Nature Communications Here, the authors look at present day and medieval genome samples from Northern France to piece together demographic history and population structure across Brittany and the Loire basin.

www.nature.com/articles/s41...

q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

Here's the link to the system, try it! qedscience.com
@qedscience.bsky.social

An error has occurred Research Square is a preprint platform that makes research communication faster, fairer, and more useful.

www.researchsquare.com/article/rs-7...

Loops of DNA Equipped Ancient Life To Become Complex | Quanta Magazine New work shows that physical folding of the genome to control genes located far away may have been an early evolutionary development.

www.quantamagazine.org/loops-of-dna...

Check out our paper on intricate nested interactions between viruses and virus satellites of haloarchaea and their nanosized DPANN symbionts. Excellent collaboration with @deemteam.bsky.social, @anagtz.bsky.social and Michail Yakimov
Free access link: rdcu.be/eLtCH
🧵 by @yifanzhou.bsky.social 👇

Origins of life: the possible and the actual | Philosophical Transactions of the Royal Society B: Biological Sciences The questions of how life forms, whether life is an inevitable outcome and how diverse its presentation could be remain some of the most profound in science. Investigations into the origin of life con...

royalsocietypublishing.org/doi/10.1098/...

A new family of ribosome hibernation factors in Archaea Ribosome hibernation preserves translation machinery during stress, yet its mechanisms in Archaea remain poorly defined. Here we identify Hib, a previously unrecognized family of archaeal hibernation ...

www.biorxiv.org/content/10.1...

From space science to dinner plates: Reimagining the future of farming indoors Extreme weather events, from heavy rainfall to heat waves and droughts, are increasingly threatening crop yields globally, so new solutions are needed for agriculture.

Controlled environment agriculture enables year-round indoor crop production with higher yields and reduced resource use, offering a resilient supplement to traditional farming amid increasing climate challenges. doi.org/g95j6g

(p)ppGpp-dependent activation of gene expression during nutrient limitation | mBio Bacteria often experience nutrient limitation and, in response, attenuate energetically costly metabolic processes like protein synthesis. At the same time, however, they stimulate the expression of a subset of proteins that facilitate survival under ...

(p)ppGpp-dependent activation of gene expression during nutrient limitation

#mBio from Jonathan Dworkin

journals.asm.org/doi/10.1128/...

Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions | PNAS www.pnas.org/doi/10.1073/...

Exercise-induced DNA damage response and memory formation in mice This study reveals that acute aerobic exercise enhances memory formation through a controlled DNA damage mechanism, offering crucial insights into Alzheimer's disease (AD) prevention. This work challe...

www.biorxiv.org/content/10.1...

Bacillus subtilis RNase HII is inefficient at processing guanosine monophosphate and damaged ribonucleotides During one round of DNA replication, nearly 2,000 ribonucleoside monophosphates (rNMPs) are incorporated in place of their cognate deoxyribonucleoside monophosphate (dNMP). Given their high rate of in...

www.biorxiv.org/content/10.1...

🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast - Nature Communications The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the pho...

Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast

www.nature.com/articles/s41...

www.nature.com/articles/s41...

Staphylococcus aureus: a model for bacterial cell biology and pathogenesis | Journal of Bacteriology When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging from mild skin and soft tissue infections, such as abscesses and furuncles,...

journals.asm.org/doi/10.1128/...

Archaea thrive in harsh niches that challenge DNA integrity. 🧬 In H. volcanii, Sailer et al. revealed Cas1 & Hel308a as new Microhomology-Mediated End Joining (MMEJ) players, expanding the toolkit for archaeal genomes repair.
buff.ly/lnyY7JF

Hyperspectral reporters for long-distance and wide-area detection of gene expression in living bacteria - Nature Biotechnology Hyperspectral reporter genes allow imaging of ground bacteria from aerial vehicles

Holy cow - hyperspectral detection of bacteria at long distance.... "The bacteria were detectable outdoors under ambient light from up to 90 m in a single 4,000-m2 hyperspectral image taken using fixed and unmanned aerial vehicle-mounted cameras." 🤯
www.nature.com/articles/s41...

L'étude croise plusieurs bases collectées indépendamment sur plusieurs thématiques. Autre fait intéressant : quelques centaines de comptes sont quasiment de toutes les polémiques depuis plusieurs années. De vrais leaders dans l'art de la décohésion sociale.

Breaking Through Biology’s Data Wall: Expanding the Known Tree of Life by Over 10x using a Global Biodiscovery Pipeline Advancements in the life sciences have always been built upon our collective understanding of life on Earth. Now, the rise of generative biology - the use of AI foundation models to design, generate, ...

www.biorxiv.org/content/10.1...