Giulio Maria Pasinetti, MD, PhD

Exposure to lead and incidence of Alzheimer's disease and all‐cause dementia in the United States INTRODUCTION Growing evidence suggests lead exposure may increase dementia risk, but evidence from human studies is limited. We investigated prospective associations between lead exposure and incide.....

Here, Sung Kyun Park, et al. @umich.edu investigated prospective assoc btwn lead exposure & incident #Alzheimers & all-cause #Dementia in nationally-representative US populations.
 They found high bone lead levels can triple your risk. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Here, Nicholas Tonks, et al. @cshlnews.bsky.social found deleting or inhibiting a protein tyrosine phosphatase enzyme, PTP1B, improved cognitive behaviors & reduced Aβ burden in an #Alzheimers mouse model. Learn More @pnas.org 👉 www.pnas.org/doi/10.1073/... Overview 👉 www.cshl.edu/researchers-...

Knowledge of modifiable factors influencing age at onset of #AlzheimersDisease remains limited. In this study, Yi-Ju Li, Eden Martin, et al. utilized genetic information to uncover such factors. FULL STUDY @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina - Nature Communications This study detects Chlamydia pneumoniae in human retina and brain, increasing with AD severity. Retinal pathogen load with Aβ42 may predict AD stage. In models, infection drives Aβ deposition and NLRP...

In this study, Bhakta Prasad Gaire, Yosef Koronyo, Jean-Philippe Vit, et al. show Chlamydia pneumoniae can reach retina & trigger immune responses linked to inflammation, nerve cell death & cognitive decline. @cedarssinaihsu.bsky.social @natureportfolio.nature.com 👉
www.nature.com/articles/s41...

The microbiota–gut–brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies Alzheimer's disease (AD) is projected to become the highest-burden neurological disorder globally. Mounting evidence implicates the gut microbiome in AD pathogenesis. This scoping review of gut micr...

Alison Warren, @phdleigh.bsky.social, et al.'s new, scoping review is shedding light on the growing evidence that #Gut #Microbiome imbalances may play a key role in development & progression of #MCI & #Alzheimers. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Here, researchers Sarah Shipley, Caswell Barry, et al. investigated how disruptions in hippocampal reactivations relate to place cell stability and spatial memory deficits in #AlzheimersDisease mouse model. @ucl.ac.uk @currentbiology.bsky.social @cellpress.bsky.social 👉 www.cell.com/current-biol...

In this study, researchers Rachael Layden, Jenna Groh, Annalise Miner, et al. examined the independent contribution of #CTE neuropathology w/ #Dementia & cognitive symptoms. @alzdemjournals.bsky.social @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study AbstractContext. Obesity is associated with a high risk of vascular-related dementia with metabolic risk factors as potential mediators, but questions of c

In new genetic study, Liv Tybjærg Nordestgaard, et al. analyzed data from large populations in Denmark and the U.K., and found that #Obesity & #HighBloodPressure may play a direct role in causing #Dementia, not just increasing the risk. Learn More in #JCEM 👉 academic.oup.com/jcem/advance...

Evaluating Alzheimer's disease with the TMS-EEG perturbation complexity index Abstract. The Perturbation Complexity Index—State Transitions (PCIST) measures the complexity of the brain’s response to transcranial magnetic stimulation

Researchers Brenna Hagan, Ali Ozdemir, Andrew Budson, et al. say that measure derived from EEG combined w/ transcranial magnetic stimulation can distinguish people w/ #Alzheimers from healthy older adults by detecting reduced brain response complexity. Learn More 👉 academic.oup.com/nc/article/2...

In a NEW STUDY, researchers Barbara Brott, Aram Raissi, Carla Shatz, et al. report new evidence that amyloid beta & inflammation may act through same molecular pathway. This insight may have important implications for future #AlzheimersDisease therapies. @pnas.org 👉 www.pnas.org/doi/10.1073/...

Here, Michael Pomirchy, Pascal Geldsetzer, et al. found that vaccination against #Herpes zoster ( #Shingles ) was tied to significantly less #Dementia risk. @stanfordpress.bsky.social
@mcmasteruniversity.bsky.social Learn More @thelancet.com
👉 thelancet.com/journals/lan...

Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2 Peripheral cancer inhibits amyloid pathology and rescues cognition of Alzheimer’s disease through secretion of cystatin-c (Cyst-C), which binds amyloid oligomers and activates TREM2 in microglia and e...

INTERESTING! Can #Cancer affect #Alzheimers progression? Here, Youming Lu, et al. at Huazhong University find that a molecule produced by cancer cells can shield brain from AD in mice. Overview @nature.com 👉 www.nature.com/articles/d41... Study @cellpress.bsky.social 👉 www.cell.com/cell/abstrac...

The proportion of Alzheimer’s disease attributable to apolipoprotein E - npj Dementia npj Dementia - The proportion of Alzheimer’s disease attributable to apolipoprotein E

Here, researchers Dylan Williams, Sami Heikkinen, Mikko Hiltunen, et al. estimated extents to which clinically diagnosed #Alzheimers (AD), AD neuropathology & all-cause #Dementia attributable to common APOE alleles in four large studies.
@ucl.ac.uk

npj | dementia
www.nature.com/articles/s44...

Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers INTRODUCTION “SuperAgers” are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in ...

Here, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, et al. investigated frequency of APOE genotypes in #SuperAgers compared to middle‐aged and older adults. Learn More in #Alzheimers & #Dementia | Journal of @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Development of potent, selective cPLA2 inhibitors for targeting neuroinflammation in Alzheimer’s disease and other neurodegenerative disorders - npj Drug Discovery npj Drug Discovery - Development of potent, selective cPLA2 inhibitors for targeting neuroinflammation in Alzheimer’s disease and other neurodegenerative disorders

The cPLA2 enzyme is a critical mediator of inflammatory lipid signaling pathways. Here, Anastasiia Sadybekov, et al. at USC investigated therapeutic potential of novel cPLA2 inhibitors in modulating #Neuroinflammation in #Alzheimers. Learn More in npj Drug Discovery 👉 www.nature.com/articles/s44...

Researchers @unmhsc.bsky.social have shown OTULIN, an enzyme known for regulating immune activity, plays major role in producing tau. Disabling OTULIN stopped tau production & removed existing tau from neurons @uthsc.bsky.social @genomicpress.bsky.social👉 genomicpress.kglmeridian.com/view/journal...

"Darkness cannot drive out darkness; only light can do that… the time is always right to do what is right”. - Dr. Martin Luther King Jr.

On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!

Brian Kennedy, et al. of National University of Singapore report calcium alpha-ketoglutarate (CaAKG), naturally occurring & well studied metabolite linked to healthy aging, can reverse several memory related brain functions disrupted in #Alzheimers Aging Cell👉 onlinelibrary.wiley.com/doi/10.1111/...

This after-meal blood sugar spike may raise Alzheimer’s risk Spikes in blood sugar after eating may be more dangerous for the brain than previously thought. In a massive genetic study, people with higher post-meal blood sugar had a much greater risk of Alzheime...

Researchers Victoria Garfield, et al. report new evidence suggesting sharp increases in blood sugar following meals may raise #Alzheimers risk. Overview 👉 www.sciencedaily.com/releases/202... Learn More in #Diabetes #Obesity & #Metabolism 👉 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain-first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain u...

In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...

Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...

Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain - Per Nilsson, Karin Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Lovisa Johanss... Background Alzheimer's disease (AD) brains are characterized by increased levels of the pathogenic amyloid-β (Aβ) peptide, which accumulates into extracell...

Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.

Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...

Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

May the New Year bring you joy, happiness, peace and good health! 🎉

Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain Chaubey et al. demonstrate that restoration of brain resilience reverses advanced disease in two different mouse models of Alzheimer’s disease (AD), challenging the century-long dogma of AD irreversib...

Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...