Sudipta Mukherjee

Thanks,DionnHargreaves LabWoolner @dev-journal.bsky.social for highlighting our preprint! Curious how mechanical and chemical signaling guides axons or how frogs are excellent for this question? @franzelab.bsky.social @evapillai.bsky.social🐸🧠 check it out #xenopus #Devbio #mechanobiology

The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.

So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

In preprints: exploring developmental robustness and timing with gastruloids How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...

For an update on a set of recent preprints using gastruloids to investigate the interplay between morphogenesis, gene expression and physical parameters, on the robustness of patterning:

journals.biologists.com/dev/article/...

🤩🤩 Check out this selection of amazing images on the Node! #devbio
thenode.biologists.com/grs-developm...

Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT

eLife Latest: Publish in a format that fits Alongside Research Articles, eLife also publishes scientific discoveries in the form of Tools and Resources papers, Research Advances and Short Reports.

High impact, small size.

We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.

Find out more 👇

An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart - Nature Communications Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved at...

“Our comprehensive atlas serves as a valuable resource to the cardiovascular and regeneration scientific communities and their ongoing efforts to understand the molecular and cellular mechanisms underlying vertebrate heart regeneration.”

New work from Ying Su Lab 🇨🇳
🔗 www.nature.com/articles/s41...

“Together, our results establish this optogenetic toolkit as a potent experimental platform to rapidly, directly, and adjustably activate FGF, BMP, and Nodal signaling in zebrafish embryos.”

New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥

Are material phase transitions more than simple regulators of tissue deformability? Check our latest work uncovering that rigidity transitions can trigger cell polarity! Congratulations to @laura-rustarazo.bsky.social , @crisp-c.bsky.social and Adrián for leading this work!

Dorsal view of a five days post fertilization zebrafish larva that has been stained with acetylated alpha tubulin. Color coded for depth. Anterior to left.

Nervous system of a five-day-old zebrafish larva. Credit to Dr. Nathan Martin of @plavickilab.bsky.social. #ZebrafishZunday 🧪

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/Sl19tgH

Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration - preLights Mui and team show hyaluronic acid deposition and a soft ECM promote digit regeneration in mice.

Hyaluronic acid deposition & a soft ECM promote digit regeneration in mice. 🐁

@jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice.

#preLight ⬇️ 👀
prelights.biologists.com/highlights/h...

Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪

journals.plos.org/plosbiology/...

Pregnancy irreversibly remodels the mouse intestine Researchers at the Francis Crick Institute have found that the small intestine grows in response to pregnancy in mice. This partially irreversible change may help mice support a pregnancy and prepare ...

Researchers at the Crick have found that pregnancy in mice leads to the irreversible growth of their small intestine.

www.crick.ac.uk/news/2025-03...

Tomohisa Toda mit Joseph-Altman-Award geehrt Tomohisa Toda, Professor für neurale Epigenomik an der Friedrich-Alexander-Universität Erlangen-Nürnberg, erhält den Joseph-Altman-Award.

Prof. Tomohisa Toda erhält den Joseph-Altman-Ward 🏆 Herzlichen Glückwunsch!

Toda untersucht den Alterungsprozess des menschlichen Gehirns anhand von langlebigen zellulären Komponenten. Der Preis ist mit 10.000 US-Dollar dotiert.

👇 Mehr erfahren: www.fau.de/2025/03/news...

Cover of issue 5: A 3D reconstruction from a light-sheet fluorescent microscopy image stack depicts parallel networks of vessels (PECAM1+, CD31, magenta) and nerves (PRPH+, yellow) in a human heart at 10.0 post-conceptional weeks. Whole-organ immunofluorescence was used to examine the spatial arrangement of blood vessels and peripheral nerves during human heart development. See Research Article by De Bono et al.

Issue 5 is complete!

On the cover: A 3D reconstruction from a light-sheet fluorescent microscopy image stack depicts parallel networks of vessels (PECAM1+, CD31, magenta) and nerves (PRPH+, yellow) in a human heart at 10.0 post-conceptional weeks. See De Bono et al.
doi.org/10.1242/dev....

3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪

Recent work from our lab: Niepukolie Nipu shows that methylene blue, at recommended concentrations used in embryo medium, affects metabolism and behaviour in larvae. These findings point to an overlooked confound relevant to larval zebrafish use in (eco)toxicity testing and the zebrafish community.

Measuring and manipulating mechanical forces during development - Nature Cell Biology This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

The flyer for the Gulmohar Episode 5 event hosted by InSDB. The flyer features two speakers: Kirti Gupta and Neha Ghosh. The event is scheduled for March 11, 2025, at 6 PM IST. The design includes the InSDB logo and a bright red decorative background.

The next set of Gulmohar talks is here!

We have Kirti Gupta from @rashmi-priya.bsky.social lab at @crick.ac.uk and @nehaghosh.bsky.social from Treisman lab at NYU School of Medicine.

🗓️March 11
⏰6 PM IST

If you haven't signed up to be a participant before, use this link: forms.gle/gGnZbd6w9yTi...

Frog!

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Sarah Bray to the left, text to the right 100 extraordinary biologists Sarah Bray Sarah Bray is the current Chair of the Board, having been a Director since 2016 and a Professor at the University of Cambridge, UK with a research interest in Notch signalling. #100biologists #biologists100

Our latest extraordinary biologist is Sarah Bray, Chair of our Board of Directors. To learn more about Sarah's role and relationship with @biologists.bsky.social, read this interview in @dev-journal.bsky.social: bit.ly/3CEibaX.
#100biologists
@uniofcam.bsky.social

Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids Dingare et al. identified a critical role for mannose-dependent glycosylation during early mesoderm specification both in mouse embryonic stem-cell-derived gastruloids and in gastrulating mouse embryo...

Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids: Developmental Cell www.cell.com/developmenta...