Dave Barefield

New work in JGP from the Barefield Lab!
Myosin binding protein H-like (terrible name) and its big brother, myosin binding protein-C have similar C'-terminal regions. Nonsense mutations in C protein are well known to prevent sarcomere incorporation. But what about this relatively unstudied paralog?

I had very little time to enjoy having gotten this particular boulder to the top of the hill this morning.

Oak Park resident Scott Sakiyama reports feds pointed weapons at him across from an elementary school today. They then arrested him and took him to Broadview. While in custody, he saw agents texting in a group chat called "Chiraq Team 2."

Full testimony: www.facebook.com/share/p/1GqB...

The Cardiovascular Research Institute team from @loyolachicago.bsky.social had a blast at the AHA #heartwalk25 walking 3 miles and raising money to fight heart disease!

American Heart Association Heart Walk The Heart Walk is the American Heart Association's premiere event for raising funds to save lives from USA's #1 and #5 killers - heart disease and stroke.

Supporting research is more important than ever. Please consider supporting the American Heart Association by supporting the Heart Walk team for Loyola University Chicago's Cardiovascular Research Institute.

Any donation is greatly appreciated!

Click here to donate now: bndfr.com/3s59Z

This is what the Zapruder film would look like today, isn't it?

Congrats Jillian!

A friendly reminder that the NIH Public Access Policy IS NOT “you must publish open access” but rather “you must ensure your copy of your paper is deposited into PubMed Central.”

Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.

NIH progress on new R01s in FY 2025 I know Doctor Editor Director Professor Berg has more sophisticated analyses going but this simple data set made sense to me once I realized how few new R01 NIAAA has issued so far (5). Since we ar…

NIH progress on new R01s in FY 2025 drugmonkey.wordpress.com/2025/08/18/n...

Rainbow at sunset over the Chicago skyline on June 30th 2025.

Great sunset shot for the end of Pride month.

Tailored therapeutics for cardiomyopathies Nature Reviews Cardiology, Published online: 27 June 2025; doi:10.1038/s41569-025-01183-6Treatment of cardiomyopathies has historically focused on symptom management. In this Review, Elliott and colleagues discuss how elucidation of the complex cellular and molecular pathways has led to the development of novel therapeutic agents that modify or mitigate the effects of causative genetic variants, enabling tailored treatment for cardiomyopathies.

New online! Tailored therapeutics for cardiomyopathies #CardioSky

🚨 Editor's Choice! 🚨 Research from University of Arizona shows L348P point mutation in cardiac myosin binding protein-C alters transient responses to stretch, slows cardiac relaxation & is embryonic lethal in homozygous CRISPR gene-edited mice

Read: doi.org/10.1016/j.yj...

David R. Hagen just solved a small mystery that I mentioned 13 years ago in the mouseover text of a comic drhagen.com/blog/the-mis...

The changing spectrum of cardiovascular diseases Advances in cardiovascular disease prevention are often hailed as one of the major public health accomplishments of the past 50 years. The progress achieved is rooted in efforts challenging the inevit...

The shift in cardiovascular disease. From reduction of heart attacks, coronary artery disease, and strokes to more atrial fibrillation ("the most common cardiovascular problem")

www.thelancet.com/journals/lan...

Today's XKCD is a great excuse to plug Loyola's @loyolachicago.bsky.social Master of Science in Clinical and Applied Proteomics:
www.luc.edu/stritch/cell...

#massspec @jonathankirk.bsky.social

Thanks! I've wondered about this building for years.

Thanks for sharing that. Interesting piece of history! It's neat that they incorporated the original facade into the new building.

Cool study! Also, noteworthy Kenneth enrichment in the author list.

6337 Roosevelt Rd. It's in Berwyn, but this multi-unit building has a pretty typical front facade and then a post-modern rear facing "atrium". I've always wanted to know how this came about.

a lego batman and a lego beaky are standing next to each other ALT: a lego batman and a lego beaky are standing next to each other

When you revise a rejected grant and it gets funded as a new A0.

From the labrats community on Reddit Explore this post and more from the labrats community

From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪

www.reddit.com/r/labrats/s/...

📢 AHA BCVS Early Career Webinar!
Please join our upcoming webinar: "Jumpstart Your Independent Academic Career: Writing a Successful Transitional/Mentored Research Grant". We have an excellent panel with a center director, grant reviewers and K awardees!

@ahascience.bsky.social

Wondering if it could be any colder outside? Yes! Come to Chicago! Accepting applications now for summer 2025 research experience in cardiovascular physiology for undergrads! Email applications to surph@luc.edu.

Cool story! Excited to see where you take this topic next!

When you're trying to keep yourself motivated but then you remember survivorship bias.

Seasonal contribution to #FluorescenceFriday.

Neonatal rat cardiomyocytes with their sarcomeres stained green. Red staining is under peer review.

Me every time I sit at my desk after a few weeks of grant rejections.

Great resume! Being on the basic science side, I always value connecting with the cardiomyopathy patients who this is all for. It doesn't happen as often as I'd like. Thank you for your patient advocacy, especially as a physician!

I've never shown a badge without channeling this scene.

Three generations of myosin binding protein researchers.

Great job @karaujo95.bsky.social presenting your BCVS poster! #AHA24