Pugh Lab

’We couldn’t live without it’: the UCSC Genome Browser turns 25 After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.

After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact

https://go.nature.com/40wPxkB

2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI This is "2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI" by AMIA on Vimeo, the home for high quality videos and the people who love them.

For those of you who may not have known him, Dr. Atul Butte, a pioneer in informatics, was the winner of the 2024 Morris F. Collen award, a pinnacle achievement in our field, as part of his storied career.

His passing is a major loss to us all.

RIP Dr. Butte

#MedSky

Excited to share our first lab paper, now published in Developmental Cell @cellpress.bsky.social !

🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?

Cell therapy has revolutionized cancer treatment. Now, its potential is expanding far beyond.

Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...

Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...

New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

Opinion: Canada can be the global leader in medical research As the U.S. slashes funding to its research initiatives, there is a chance for us to recruit the best talent from around the world

It's time for Canada to Lead

www.theglobeandmail.com/opinion/arti...

An illustrated diagram of the biologic features of extrachromosomal DNAs

A recent study shows how extrachromosomal DNA contributes to tumor heterogeneity and may drive cancer progression. Learn more: nej.md/42jfYdH

#MedSky #Oncology #Genetics

The Allan Slaight Breakthrough Forum brought together 60+ scientists from Princess Margaret Cancer Centre, Krembil Research Institute, and CAMH to explore the links between cancer, neuroscience, & mental health. Looking forward to the exciting discoveries ahead!

www.uhnresearch.ca/news/advanci...

Canada’s U.S. brain gain is risky without more foundational support for science Scientists want to come to Canada not only to escape the chaos and uncertainty emerging in U.S. science but also because they are drawn to the energy here

Excellent Op-Ed by Peter Zandstra on improving 🇨🇦 science at a time when 🇺🇸 is throttling their golden goose. Instead of bespoke, targeted & ultimately short term solutions limited to a few people, build a deep, more attractive ecosysyem. The best will thrive. www.theglobeandmail.com/gift/46242ee...

We're excited to join Bluesky! Follow us for the latest news about cBioPortal.

Welcome to the March 2025 edition of the cBioPortal Newsletter! As we step into 2025, we're excited to share the latest updates and enhancements in cBioPortal. cBioPortal is hosting Google Summer of Code (GSoC) 2025 We are excited to announce that cBioPortal has o...

First newsletter of 2025! Read to get the latest news and all the details on GSoC 2025 projects and application process #cBioPortal #newsletter #gsoc2025 www.linkedin.com/pulse/welcom...

Postdoctoral Fellow - Computational - Toronto (Region), Ontario (CA) job with Princess Margaret Cancer Centre | 12836915 We a seeking applications for a computational postdoctoral fellow with expertise in cancer epigenomics, chromatin biology, and data-driven research.

🇨🇦 Fast-track your computational biology/bioinformatics career in cancer research! 🇨🇦

The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.

Apply now: www.nature.com/naturecareer...

Epigenomic heterogeneity as a source of tumour evolution - Nature Reviews Cancer Single-cell epigenomic technologies are refining our understanding of cancer evolution.

#REVIEW

Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
📖 👉 https://bit.ly/40PCQ...

Ultra-processed food? Forever chemicals? Declining birth rates? What’s behind rising cancer in the under-50s? Research into the disease has never been more far-reaching, but there is little consensus as to what is causing the rocketing rates of diagnosis in young adults

Rates of #cancer in #young #adults have risen dramatically in recent years - as discussed in this article..

We urgently need to invest in #research 🧪 on early-onset cancers to understand - why?

www.theguardian.com/science/2025...

Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223 Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...

Indeed, there are a number of open positions for early career investigators in Toronto. It's a great city in a great country to pursue impactful science.

Seems like a perfect day to consider continuing your research career in beautiful Canada! Recruiting an ECR in cancer research, a week left to apply.

Absolutely thrilled to see the next next-generation sequencer arrive on our doorstep. Looking forward to affordable deep dives into cell-free genomes. Will we be able to reconstruct cancer genomes from blood without a biopsy, even for early cancers? We think so!