Molecular Omics

Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking Although multi-omics analysis is popular for revealing diverse physiological effects and biomarkers in many branches of state-of-the-art molecular and cell biology and bioinformatics, there is still…

🔓Be sure to read this #OpenAccess paper from Olga Kovalchuk, Igor Kovalchuk & co. at @ulethbridge.ca in our latest issue reporting multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking #omics

Find it in full below👇

MOFNet: a deep learning framework for multi-omics data fusion in cancer subtype classification Background: cancer exhibits high molecular and clinical heterogeneity, making accurate subtyping essential for personalized treatment. Traditional single-omics approaches often fail to capture this…

Don't miss this research by Zhi-Ping Liu et al. at Shandong University describing a new deep learning framework for multi-omics data fusion in cancer subtype classification, in our latest issue #omics #bioinformatics

Check out their full report on our website🔽

Deep learning methods and applications in single-cell multimodal data integration The integration of multimodal single-cell omics data is a state-of-art strategy for deciphering cellular heterogeneity and gene regulatory mechanisms. Recent advances in single-cell technologies have…

Check out this review in our latest issue by Guilherme da Silva Fernandes, Márcio Dorn & co. from Federal University of Rio Grande do Sul looking at deep learning methods & their application in single-cell multimodal data integration #bioinformatics #omics

Read it here👇

Mapping the Helichrysum metabolome: uncovering species-specific chemistry through an AI-guided LC-MS/MS workflow Helichrysum species, of which 35% are native to South Africa, are renowned for their diverse medicinal properties, yet their chemical composition remains largely unexplored. As such, continuous…

Take a look at research from @fideletu.bsky.social et al. in our latest issue mapping the metabolome of Helichrysum species through an AI-guided LC-MS/MS workflow #metabolomics

📍University of Johannesburg, University of Venda

Global spinal cord peptidome profiling in response to osteoarthritis in rats Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an…

Be sure to read in our latest issue research by Eric Troncy, @liresearch.bsky.social & co. from @uwmadison.bsky.social & @umontreal.ca revealing how osteoarthritis reshapes the spinal cord peptidome in rats #proteomics

Find the full article here🔽

Mass spectrometry-based profiling of phosphoinositide: advances, challenges, and future directions Phosphoinositides (PIPs), the phosphorylated derivatives of phosphatidylinositol (PI), are low-abundance yet critical components of eukaryotic membranes. They play pivotal roles in a wide array of…

🔓Don't miss this #OpenAccess review by Nozomu Kono et al. @utokyoofficial.bsky.social in our latest issue discussing the advances, challenges & future directions of mass spectrometry-based profiling of phosphoinositide #lipidomics

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Comparative glycomic analysis of hawk (Rupornis magnirostris), caiman (Caiman latirostris) and sea turtle (Caretta caretta) tear films Glycans are recognized as biomarkers and therapeutic targets. However, these molecules remain a critical blind spot in understanding post-translational modifications, particularly in vertebrate…

Check out research by Arianne Oriá & co. at Federal University of Bahia & @ucdavis.bsky.social using glycomics of hawk, caiman and sea turtle tears to show how habitat affects the glycans involved in eye protection #glycomics

Read in full on our website🔽

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk Chronic inflammation plays a central role in the progression of both infectious and vascular diseases, yet its impact on endothelial cells (ECs), which form the interface between blood and tissue,…

🔓Take a look at #OpenAccess research from Vinod Kumar et al. in our latest issue showing how cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk #omics

📍 @radboudumc.bsky.social, @rug.nl & @utwente.bsky.social

DeSciDe: a tool for unbiased literature searching and gene list curation unveils a new role for the acidic patch mutation H2A E92K Omics analysis has become an indispensable tool for researchers in the life sciences, enabling the study of DNA, RNA, and proteins and how they respond to cellular stimulus. Many methods of data…

🔓Be sure to read this #OpenAccess research in our latest issue by Cameron J. Douglas & @ciaranseath.bsky.social from @wertheimufscripps.bsky.social reporting DeSciDe: a new tool for unbiased literature searching and gene list curation #omics

Find the full article below👇

Don't miss the research providing the inside front cover of our latest issue from Dharmendra Singh Bhadauria, Neeraj Sinha & co. at SGPGIMS characterizing metabolic dysregulation in early-stage chronic kidney disease #metabolomics

Check it out in full here🔽
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Promotional image for a 24-hour online conference on LinkedIn by American Elements and the Royal Society of Chemistry, scheduled from March 3, 2026, at 12:00 GMT to March 4, 2026, at 12:00 GMT. Features an orange and black design with abstract lines and dots, highlighting the text 'Save the date'.

📢 Save the Date! We’re delighted to announce that #RSCPoster 2026 will take place on 3 March 2026 at 12:00 GMT.

Join researchers from around the world for a day of sharing, connecting, and celebrating scientific creativity across disciplines.

Mark your calendars — more details coming soon!

📢Our last issue of the year is now online!

Check out the research behind the front cover by Chintamani, Abhinav Kumar, Néel Sarovar Bhavesh et al. from ICGEB on how differentially regulated saliva proteome and metabolome can be used for risk-assessment of oral cancer

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Don't miss research in our latest issue by Bikash Baishya, Dharmendra Singh Bhadauria et al. at Sanjay Gandhi Postgraduate Institute of Medical Sciences on understanding metabolic alterations in advanced stage chronic kidney disease patients by NMR-based metabolomics

Integrated multi-omic analyses of bovine milk identify biomarkers of negative energy balance Dairy cows are susceptible to negative energy balance, which can lead to metabolic disorders such as ketosis. Negative energy balance (NEB) often occurs in early lactation, but can also be due to…

Check out in our latest issue a paper by Fabienne Le Provost & co. from @inrae-france.bsky.social using integrated multi-omic analyses of bovine milk to identify biomarkers of negative energy balance #multiomics

Read it in full here👇

Proteomic and metabolomic dissection of the BRAF V600E mutation-induced cellular state transition in lung epithelial cells Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and 4% of NSCLC patients are reported to harbor mutations in BRAF, which encodes a serine/threonine kinase capable of…

Take a look at research from Jimin Yuan, Lin Jia, Lingyun Dai & co. in our latest issue using proteomics & metabolomics to dissect the BRAF V600E mutation-induced cellular state transition in lung epithelial cells #multiomics

📍Shenzhen Technology University, SUSTech

POMC-specific modulation of metabolic and immune pathways via melanocortin-3 receptor signaling This proteomic study provides a nuanced mechanistic understanding of the signaling processes upon agonist binding to the melanocortin-3 receptor (MC3R). Utilizing thermal proteome profiling (TPP)…

🔓Be sure to read in our latest issue this #OpenAccess paper from Erik T. Jansson et al. at @uu.se using proteomics to uncover POMC-specific modulation of metabolic and immune pathways via melanocortin-3 receptor signaling #proteomics

Find it in full on our website🔽

Global spinal cord peptidome profiling in response to osteoarthritis in rats Osteoarthritis (OA) is a complex and increasingly prevalent condition, affecting an estimated 600 million people worldwide and significantly reducing quality of life. Understanding OA as both an infla...

New publication on @molecularomics.rsc.org 🥳Our work revealed how osteoarthritis reshapes the neuropeptide landscape of the spinal cord in the MIRAT model. This is a nice collaboration with Prof. Eric Troncy Lab, and congrats to Gaoyuan, Marilyn and all co-authors 👏
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Temperature- and time-dependent degradation of mouse tissue proteins: insights into RNA-binding protein stability via mass spectrometry In proteomics research, samples are frequently stored at −20 °C and −80 °C for extended periods, and assessing protein stability under these conditions is essential. We evaluated protein stability in…

Don't miss research in our latest issue using mass spectrometry to provide insights into temperature- and time-dependent degradation of mouse tissue proteins by Ramalingam Peraman & co. from NIPER Hajipur #proteomics

Check it out in full below👇

Advancing colorectal cancer research through lipidomics Colorectal cancer (CRC) is currently a global health burden, with staggering worldwide prevalence. CRC is ranked as the third most common and second deadliest cancer worldwide. With rising life…

🔓Check out this #OpenAccess review from Editorial Board member Rosario Domingues & co. at the University of Aveiro looking at the recent advancements in colorectal cancer research driven by lipidomics #lipidomics

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Transcriptome and proteome analyses reveal the virulence of the Vibrio alginolyticus effector gene vopR Vibrio alginolyticus is an opportunistic infectious pathogen, and its pathogenicity is related to various virulence factors, with the type III secretion system (T3SS) being one of the important…

Take a look in our latest issue at research on how transcriptome and proteome analyses reveal the virulence of the Vibrio alginolyticus effector gene vopR by Min Tao et al. #proteomics #omics

📍Neijiang Normal University

Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in caveolin-1 null mice Mice lacking caveolin-1 (Cav1), a major protein of the lipid raft of plasma membrane, show deregulated cellular proliferation of the mammary gland and an abnormal fetoplacental communication during…

Be sure to read this paper by Susanta K. Behura & co. from the University of Missouri using multi-omics to investigate mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signalling in caveolin-1 null mice #omics #multiomics

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Thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells The development of acquired resistance to tamoxifen poses a significant clinical challenge in breast cancer treatment. Tumour heterogeneity has emerged as a primary reason for the clinical…

Don't miss this research in our latest issue looking at how thioridazine induces phospholipid accumulation and necroptosis in parental and tamoxifen-resistant breast cancer cells from Sudhagar Selvaraju et al. at NIPER Guwahati #omics

Check out the article in full here🔽

📢Issue 5 of Molecular Omics is online!

Check out the paper behind the cover by Patricia Pascual-Vargas, @cbakal.bsky.social & co. from @icr.ac.uk on how integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC

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PPI network identifies interacting pathogenic signaling pathways in Candida albicans Candida albicans, an opportunistic and systemic infection causing fungus, causes skin, nail, and mucosal layer lesions in healthy individuals and hospital borne catheter-related and nosocomial…

Take a look in our latest issue at an article from Achintya Mohan Goswami, Tanima Saha on how a PPI network identifies interacting pathogenic signaling pathways in Candida albicans

📍University of Kalyani

Analysis of FAIMS for the study of affinity-purified protein complexes using the orbitrap ascend tribrid mass spectrometer In this study, we analyzed the combination of affinity purification mass spectrometry (AP-MS) with high-field asymmetric waveform ion mobility spectrometry (FAIMS), integrated between nanoLC-MS and…

Be sure to read research from our Associate Editor Michael Washburn et al. @kuhospital.bsky.social in our latest issue describing an analysis of FAIMS for the study of affinity-purified protein complexes using the orbitrap ascend tribrid mass spectrometer #proteomics

Lipid profiling: proving the geographical origin of strawberries (Fragaria × ananassa) using a non-targeted LC-IM-MS approach The strawberry, a globally traded fruit, is a prime example of how geographical origin has become an important marketing factor. Significant price differences between countries of origin make…

🔓Don't miss in our latest issue a paper on using a non-targeted LC-IM-MS approach of lipid profiling to prove the geographical origin of strawberries from Markus Fischer & co @uni-hamburg.de #lipidomics

Check out the full article on our website🔽

Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO2-NP) exposure The increasing exposure to nanoparticles raises a concern over their toxicity. Incidentally, reactive oxygen species (ROS) are produced as a result of the nanoparticle's physicochemical…

Check out research by Jeganathan Manivannan & co from Bharathiar University in our latest issue on human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during TiO2-NP exposure

Read it in full below👇

Integrating N-glycan and CODEX imaging reveal cell-specific protein glycosylation in healthy human lung Identifying cell-specific glycan structures in human lungs is critical for understanding the chemistry and mechanisms that guide cell–cell and cell–matrix interactions and determining nuanced…

Take a look in our latest issue at a paper by Dušan Veličković et al. on integrating N-glycan and CODEX imaging to reveal cell-specific protein glycosylation in healthy human lung #glycomics

📍Pacific Northwest National Laboratory & @urochester.bsky.social

A multi-omics machine learning classifier for outgrowth of cow's milk allergy in children Cow's milk protein allergy (CMA) is one of the most common food allergies in children worldwide. However, it is still not well understood why certain children outgrow their CMA and others do not.…

🔓Be sure to read #OpenAccess research from Clara Belzer & co at @w-u-r.bsky.social & @unileiden.bsky.social describing a multi-omics machine learning classifier for outgrowth of cow's milk allergy in children #multiomics

Find the full article on our website🔽

Don't miss the article behind the inside front cover of our latest issue from Preeti Tiwari, Chandan Singh et al. at Banaras Hindu University on metabolomics-based predictive biomarkers of oral cancer and its severity in human patients from North India using saliva

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