Transposon and Cancer Epigenetics Group

Only 6 days left to apply! We’re recruiting a PhD student to study the immunogenic roles of transposable elements in pediatric AML. The project involves working with clinical trial samples in collaboration with Dr. Richard Dillon (KCL). If interested, get in touch!

Come and join us to discover immunogenic potential of transposable elements in pediatric AML as part of CRUK CoL PhD programme.

We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...

Fun obviously, not fund 😅

The usual one, nil.

Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...

Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...

🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)

QMUL Centre for Epigenetics Launch Conference 2025 Join us in celebrating becoming an official Centre for Epigenetics at QMUL!

Less than a month left until the Centre for Epigenetics Launch Conference! 🚀The scientific programme encompasses both oral and poster presentations by invited speakers and selected abstract submissions. There is still time to book your free ticket here: www.eventbrite.co.uk/e/qmul-centr...

Terrible news. So sorry Marco :/

Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

This EHA meeting was a blast! Great to see so many of the leaders in the field and young minds!

Amazing news update :) Well done!

QMUL Centre for Epigenetics Launch Conference 2025 Join us in celebrating becoming an official Centre for Epigenetics at QMUL!

We're excited to announce the official QMUL Centre for Epigenetics Launch Conference 2025! 🎉 To find out more and book your free ticket, please follow the link below:
www.eventbrite.co.uk/e/qmul-centr...

@qmul.ac.uk

@bartscharity.bsky.social

@qmulepigenetics.bsky.social

OPPORTUNITY TO JOIN US!

Two of these PhD positions are available in our group.

We want to know how nuclear metabolism impacts chromatin regulation in leukaemia.

You as well?
> Then check this out!

!THREE OPPORTUNITIES TO JOIN US!

We are looking for 3 (!!!) PhD students interested in:
How Metabolism affects Genome Regulation.

Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow.

More info:
2 x experimental: www.nuclear-dn.eu
1 x computational: www.hubmol.eu

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/

www.encodeproject.org/single-cell/...

L1-ORF1p nucleoprotein can rapidly assume distinct conformations and simultaneously bind more than one nucleic acid Abstract. LINE-1 (L1) is a parasitic retrotransposable DNA element, active in primates for the last 80–120 Myr. L1 has generated nearly one-third of the hu

How does the ORF1p perform its multiple functions to facilitate LINE1 retrotransposition? And what enables its ability to also facilitate replication of other retrotransposons? Find out in our newly published paper in Nucleic Acids Research doi.org/10.1093/nar/...

Thrilled to announce the EHA Research Conference 2025!
Join us for a stellar line-up of talks on: ✨Transcriptional Control and Chromatin Alterations in Normal and Abnormal Hematopoiesis✨
🗓️ Abstract deadline: Jan 8, 2025
📌 Details & personalised flyer below—don’t miss it! ehaweb.org/meetings/eha...

Looking forward to it!!

Thanks :)

Thanks for putting this together. Could you please add me as well :)

We are looking for a postdoctoral data scientist position to join our supportive and fun group :) Join us @QMBCI in vibrant #London to delve into the analysis of repetitive genome in #cancer! We support for visa applications, career and personal development! www.jobs.ac.uk/job/DFN649/p...

Post-Doctoral Research Assistant at Queen Mary University of London An opportunity for an academic position as a Post-Doctoral Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

Postdoc position in Rakyan Lab! The position will focus on the molecular basis of differences in translational output amongst different ancestries in humans, combining proteomics, genomics and computational approaches. Please do email me for further info!

www.jobs.ac.uk/job/DFL087/p...

Great. Thanks for setting this up :)

Thanks for tagging this. Hm I also don’t know and tried to experiment it :)

We are looking for a postdoctoral data scientist to join our group in London, TEworldwide

We are looking for a postdoctoral data scientist position to join our supportive and fun group :) Join us @QMBCI in vibrant #London to delve into the analysis of repetitive genome in #cancer! We support for visa applications, career and personal development! www.jobs.ac.uk/job/DFN649/p...

Enhanced transposable elements - Nature Reviews Cancer Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver cancer cell lines.

The non-coding repetitive genome as a source of regulatory DNA elements in cancer: a highlight of the recent work from
Biswajyoti Sahu: www.nature.com/articles/s41...

Totally agree. Having kids is challenging in any stage of academia. Waiting for a good time is not realistic. But having mine during postdoc helped me to be more productive with shorter not so flexible working hours and probably healthier working conditions :)