Satoshi Endo

Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction - Acta Pharmacologica Sinica Acta Pharmacologica Sinica - Nicotinamide mononucleotide protects septic hearts in mice via preventing cyclophilin F modification and lysosomal dysfunction

Mice: "This study demonstrates that NMN modulates the interplay of mitochondrial ROS and PPIF in maintaining normal lysosomal function and autophagy and protecting ATP5A1 and ATP production during sepsis."
APS/Nature (Abstract): www.nature.com/articles/s41...

A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....

Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization!
onlinelibrary.wiley.com/doi/abs/10.1...

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways | PNAS A hallmark of neurodegenerative diseases (NDs) is the progressive loss of proteostasis, leading to the accumulation of misfolded proteins or protei...

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways | PNAS www.pnas.org/doi/10.1073/...

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
www.nature.com/articles/s41...

Reactive oxygen species control protein degradation at the mitochondrial import gate This work identifies reactive oxygen species released by the electron transport chain as sentinel molecules that regulate localized protein degradation at mitochondrial TOM complexes, a mechanism that controls mitochondrial protein import and adjusts the abundance of the electron transport chain to cellular needs.

Reactive oxygen species control protein degradation at the mitochondrial import gate: Molecular Cell www.cell.com/molecular-ce...

USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer - Cell Death & Differentiation Cell Death & Differentiation - USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer

USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in #PancreaticCancer 🧪 www.nature.com/articles/s41...

Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...

Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪 #chembio #TPD #CancerResearch

www.biorxiv.org/content/10.1...

Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase | PNAS The maintenance of cholesterol homeostasis is crucial for normal function at both the cellular and organismal levels. Two integral membrane protein...

Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase
www.pnas.org/doi/10.1073/...

Autophagy3D: a comprehensive autophagy structure database Abstract. Autophagy pathway plays a central role in cellular degradation. The proteins involved in the core autophagy process are mostly localised on membr

Autophagy3D: a comprehensive autophagy structure database
academic.oup.com/database/art...

Development of a p62 biodegrader for autophagy targeted degradation Harnessing autophagy for targeted degradation is a promising extension to proteasome-based targeted protein degradation because of the capacity and versatility of lysosomes to degrade large and comple...

Development of a p62 biodegrader for autophagy targeted degradation
www.biorxiv.org/content/10.1...

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
www.nature.com/articles/s41...

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.

The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation.
www.science.org/doi/10.1126/...