Kia Movahedi

🙏🏼🙏🏼

Thanks so much for the wonderful spotlight piece Jingyi Yang!

Microglia replacement: from monocytic origin to therapy Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aise…

Hello world! My first post here, and it's a special one!

I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology!

Read it here: www.sciencedirect.com/science/arti...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. ...

The @movahedilab.bsky.social lab shows in the @cp-immunity.bsky.social paper that monocytes are capable of efficiently replacing microglia and border-associated macrophages. Congrats for this beautiful work www.cell.com/immunity/ful...

Reviews and perspectives from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Michela Matteoli, Oleg Butovsky, Brian Kim, David Artis, & Marco Prinz!

Thanks so much Roman!

Border-associated macrophages as gatekeepers of brain homeostasis and immunity Specialized immune cells called border-associated macrophages (BAMs) guard the brain’s outer tissues, where they help maintain homeostasis and protect against disease. In this review, Vara-Pérez and Movahedi explore how BAMs develop, how they can be classified, what roles they play, and why they matter for brain health. The authors integrate recent discoveries to highlight how BAMs support and defend the brain.

Online now: Border-associated macrophages as gatekeepers of brain homeostasis and immunity

Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

We used microglia replacement to understand the therapeutic and pathologic roles of macrophages in a genetic brain disease 🧠

A 🧵 on my first author work from the Bennett Lab (+ the paper) below! ⬇️

www.cell.com/immunity/ful...

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace.

Congrats to first author Jonathan Bastos!

Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia Microglia and border-associated macrophages (BAMs) are critical for brain health, and their dysfunction is associated to disease. Replacing brain macr…

Very happy for having contributed to this amazing study led by Jonathan Bastos and Kia Movahedi. Super cool findings! @sotonbiosciences.bsky.social @cp-immunity.bsky.social @liambc.bsky.social

www.sciencedirect.com/science/arti...