Bob Varelas

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01.03.2025 10:22 — 👍 193    🔁 79    💬 7    📌 6

LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche | EMBO reports imageimageLATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro-oncogenic stromal niche. Inhibitors of YAP/TAZ-TEAD activity blo...

Despite the chaos and uncertainty, I am happy to share our latest publication. In this study, we mapped stromal changes in mammary carcinomas initiated by epithelial LATS1/2 kinase inhibition and demonstrated the effectiveness of TEAD inhibitors in this model.

www.embopress.org/doi/full/10....

15.02.2025 12:59 — 👍 6    🔁 1    💬 0    📌 0

Bob Varelas and co-workers @varelaslab.bsky.social @bumedicine.bsky.social @bostonu.bsky.social show that LATS1/2 inactivation in the mammary #epithelium drives the #evolution of a #tumor-associated #niche. #hippo #cancer #TEAD

www.embopress.org/doi/full/10....

15.02.2025 07:53 — 👍 4    🔁 1    💬 0    📌 0

Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis - Nature Communications The regenerative capacity of the lung in response to injury deteriorates with aging. Here, Raslan et al. discover that aging-associated progressive lung fibrosis is accompanied by persistent activatio...

Great collaborative study with Giovanni Ligresti’s lab is out! We identify age-related lung endothelial cell states that associate with injury-induced fibrosis.
www.nature.com/articles/s41...

05.07.2024 14:10 — 👍 5    🔁 0    💬 1    📌 0

Generation of human alveolar epithelial type I cells from pluripotent stem cells Kotton and colleagues generate human alveolar epithelial type I cells (AT1s) from induced pluripotent stem cells (iPSCs). The resulting cells can be grown as 3D organoids or in 2D air-liquid interface...

 
Recipe for making pulmonary AT1 cells from human iPSCs just out from the Kotton lab. Great collaboration!
 
www.cell.com/cell-stem-ce...

19.04.2024 18:00 — 👍 3    🔁 0    💬 0    📌 0