The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
Did you ever wonder how good any disease predictor based only on genetic data could be? Answer: it is a function of the heritability of the markers used, and might not be very high, without ~all~ the genetic variants identified. Figure 5. www.pivotscipub.com/hpgg/4/3/000...
20.08.2024 17:30 — 👍 1 🔁 0 💬 0 📌 0
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
The Quantitative Genetics of Human Disease: 2 Polygenic Risk Scores
Did you ever wonder why polygenic risk scores seem so hard to interpret across populations? Answer: it is almost all due to allele frequency and LD differences. www.pivotscipub.com/hpgg/4/3/000...
20.08.2024 17:28 — 👍 1 🔁 0 💬 0 📌 0
If you are looking for something actually really good on AppleTv the answer is SlowHorses! Among the better shows on any platform anywhere. Very, very smart, and Oldman is worth watching independent of plot.
16.12.2023 11:29 — 👍 1 🔁 0 💬 1 📌 0
This monster of paper is entirely open source, so if you find it at all useful, please share it with your friends and trainees.
pivotscipub.com/hpgg/3/4/000...
08.12.2023 18:56 — 👍 0 🔁 0 💬 0 📌 0
Do you know what an additive by additive genetic interaction is? If you want to see a definition and a description for how to calculate such a thing for both quantitative and binary traits try pivotscipub.com/hpgg/3/4/000...
08.12.2023 18:50 — 👍 0 🔁 0 💬 0 📌 0
Have you ever wanted to know how to calculate heritability for a human disease? Have you ever wanted to know how to convert human genetics quantities like odds ratios or penetrance into their quantitative genetics equivalents?
pivotscipub.com/hpgg/3/4/000...
08.12.2023 18:47 — 👍 0 🔁 0 💬 0 📌 0
Have you ever wanted to see a derivation of fundamental quantitative genetics results without any assumption of normal distributions? pivotscipub.com/hpgg/3/4/000...
08.12.2023 18:45 — 👍 3 🔁 0 💬 0 📌 0
Annenberg Professor of Natural Sciences, University of Pennsylvania
http://evolution.sas.upenn.edu/
Evolutionary Biologist at Stanford. Rapid Evolution, Adaptation, and Genomics. Open Science advocate.
From busboy/car washer to population geneticist at UCSF, co/Director of the BMI PhD program & UCSF PREP/PROPEL Programs!!!
Genomics, big data, open science, diversity. Director of the Centre for Population Genomics, focused on building a more equitable future for genomic medicine. Opinions my own.
Theoretical biologist and advisor to data scientists at the University of Arizona. Mostly theoretical population genetics and molecular evolution, but I've also published in biochemistry, infectious disease, aging, economics, education. Opinions are my own
evolutionary genomics of maize and wild relatives. erstwhile ethnobotanist. purveyor of bad puns. dad. prof and HPC director at UC Davis. not actually a cool cow from 1994. rilab.ucdavis.edu. views, especially bad ones, mine only (he/him)
Assistant Professor in the Center for Genetic Epidemiology at USC.
My lab studies genetics and evolution.
https://www.durvasula-lab.usc.edu
My lab at Stanford studies human population genetics and complex traits.
Ray and Stephanie Lane Professor of Computational Biology at CMU School of Computer Science. https://www.cs.cmu.edu/~jianma/
Assistant professor in quantitative and computational biology @USC. Genetics, evolution, statistics. https://edgepopgen.github.io/edgelab/
Population & Human Genetics
Professor at UCLA in Ecology & Evolutionary Biology as well as Human Genetics.
Traffic Ninja. Occasional runner...
https://lohmueller.eeb.ucla.edu
Co-Founder and Chief Scientist | Venture Partner | Professor | Mentor | Proud mom of 3 ✨
USA->UK->Finland. Posting about 'omics technologies and the great outdoors (among other things).
Population and evolutionary genetics @UCDavis. Posts, grammar, & spelling are my views only. He/him. #OA popgen book https://github.com/cooplab/popgen-notes/releases
Genetics & Evolution, Faculty at Stanford & Freeman Hrabowski Scholar at HHMI
schumerlab.com
Genetics, bioinformatics, comp bio, statistics, data science, open source, open science!
Assistant professor at the University of Chicago. Studying the population genetics of complex traits (mainly) and interested in using math to understand biology.
Join my lab, where science is fun and traits are complex!
