Shervin Nia

AI just cracked de novo antibody design with a 100x leap! 🧪

Chai-2, a next-gen multimodal generative model, is shaking up protein design. With a 16% hit rate in fully de novo antibody design—over 100 times better than previous methods—it’s making drug discovery faster and more precise than ever.

The Immortal Life of Henrietta Lacks Check out The Immortal Life of Henrietta Lacks - <b>#1 <i>NEW YORK TIMES </i>BESTSELLER &bull; &ldquo;The story of modern medicine and bioethics&mdash;and, indeed, race relations&mdash;is refracted be...

This is near and dear to my heart these days.

I would highly recommend The Immortal Life of Henrietta Lacks by Rebecca Skloot if you to get emotionally invested in why investing in medical research, cancer or whatever, and approaching it ethically is so damn import.

bookshop.org/p/books/the-...

I got to the T7 shuttle pick-up area at 2:45pm last Tuesday. I waited abt 45 minutes for a shuttle that had just enough room to squeeze me in. In that time, I saw what felt like 30+ shuttles for both LAXit and FlyAway that were all mostly empty. Hope that data helps!

And I understand that the shuttle is a stopgap until the people mover opens, but so is every other shuttle system which goes frequently. Not sure if this would be on Metro or LAWA to fix, but I hope it is addressed.

I went to check out the station on my way back from a trip! The station itself is lovely, but one shuttle every 10 min is nowhere near where it needs to be to support the level of ridership this station gets. I had to wait for 3 jam-packed shuttles to go by before one had space to pick me up at T7.

#CryoSPARC v4.7 is out! 🚀 
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates

#cryoEM

I tested this out and it’s fantastic! No more breaking grids before plunging. Every facility should have these.

I printed with PLA for use with Pelco easyGlow and tested with Ultraufoil grids.

Electron microscopy grid holder by _rouillac | Download free STL model | Printables.com A simple design to hold flat CryoEM grid compatible with glow discharge. | Download free 3D printable STL models

🔬 Tired of dropping CryoEM grids during manipulation? Check out my 3D-printed holder! Download the STL file here: www.printables.com/model/900940.... Compatible with glow discharge systems, it makes your workflow smoother and more efficient. 💡 #CryoEM #3DPrinting #OpenScience

Good idea! I’ll look into setting that up soon.

DM me or @cryoempapers.bsky.social if you want a paper bot for your subfield 😃

Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1

Thanks for the kind words! I was a big fan of the bot and distinctly remember when Twitter’s API policy changed. Thanks for your original work, and I’m glad I can help restore this service to the community.

Is this list also for grad students? 😁

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Overcoming the preferred-orientation problem in cryo-EM with self-supervised deep learning pubmed.ncbi.nlm.nih.gov/39558095/

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Practical considerations for plunge freezing samples over 40 °C for Cryo-EM https://pubmed.ncbi.nlm.nih.gov/39549637/

For those who miss the cryoEM papers bot from Twitter, I’m happy to announce the new @cryoempapers.bsky.social! Let me know what you think. I will be tweaking the keywords and RSS feeds as I finalize it so I welcome any input.

Can I and my paper bot @cryoempapers.bsky.social be added? Thanks!

Hello, #bluesci! I’m Shervin Nia, a PhD candidate in the lab of Z. Hong Zhou at UCLA. Looking forward to interacting with the community here and sharing some of my projects!