Roberta Turiello

@eurjimmunol.bsky.social

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While the functional role of NKG7 continues to be explored, its consistent co-expression with cytotoxic signatures across diverse contexts makes it a powerful tool for profiling cytotoxic immune cells.

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These findings position NKG7 as a robust, versatile marker for cytotoxicity—relevant for both basic immunology and translational research in cancer and immune-mediated diseases.

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• Notably, NKG7 expression persists even in PRF1-negative populations, suggesting its utility in tracking alternative or noncanonical cytotoxic programs.
• We also showed that NKG7 is highly expressed in CD4-CTLs, an emerging effector subset in cancer immunity.

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What we found:
• NKG7 consistently marks cytotoxic immune cells — even in complex tissue environments like tumors.
• It outperforms traditional markers like GZMB and PRF1 in reliability and consistency.

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In our study, we performed a comprehensive profiling of cytotoxicity-associated transcripts across immune subsets and tissues.

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Cytotoxicity is essential for immune defense against tumors and infections, typically assessed using markers such as granzyme B (GZMB) and perforin (PRF1). However, less is known about other cytotoxic components.

NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment Cytotoxicity-associated genes exhibit heterogeneity at the cellular and tissue levels (left). NKG7 gene expression is strongly associated with a cytotoxic gene signature (middle). NKG7 expression is ...

🚨 New Paper in European Journal of Immunology!
We show that NKG7 is a robust marker of cytotoxicity, outperforming GZMB and PRF1 across immune cell types and tissues!
Thanks to all co-authors, @nsssusanna.bsky.social, @M.Hoelzel & @eomesodermin.bsky.social
📖 onlinelibrary.wiley.com/doi/10.1002/...

NKG7 is a stable marker of cytotoxicity across immune contexts and within the tumor microenvironment
www.biorxiv.org/content/10.1...
@eomesodermin.bsky.social @nsssusanna.bsky.social @rturiello.bsky.social

🔵 Tim Kempchen poster #91
🟡 Lukas Kiwitz poster #95

The inaugural conference of the European Society for Spatial Biology (#ESSB) has kicked off today in Berlin!

#IEO is here and represented by me and our PhD students Tim and Lukas. Come say hi, we got cool stories to share!

🟤 Interested in melanoma? Find me at poster #171 or shoot me a message!

The #MelanomaBridge was the first conference I attended, after starting my PhD in 2018. This year, I had the privilege of returning as a postdoc, showing some of my data.
3 days of inspiring talks and thought-provoking debates. Heading back to Bonn now, with new ideas and inspiration for my project