Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants - Nature Immunology Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform functional screening of clinically r...

Thrilled to share that our paper is now online in Nature Immunology! Huge thanks to all the amazing lab members and collaborators who made this possible. Science is a team effort, and I’m grateful to be working with such a fantastic group. #MastersLab#inflammasomes

www.nature.com/articles/s41...