Liz Worthey

This ought to be engraved somewhere.

An unarmed veteran was attacked from behind, sustaining injuries and being dragged into a Portland ice building.

It’s all Greek to me – Plato and Socrates tackle a Captcha test: the Stephen Collins cartoon Tick all the images with chariots …

Very funny cartoon from @stephencollins.bsky.social

www.theguardian.com/lifeandstyle...

I think I can perhaps get access. Will talk to the PI.

My work email is lworthey@uab.edu. Send me a note and we can chat.

My work email is lworthey@uab.edu. Send me a note and we can chat.

My work email is lworthey@uab.edu. Send me a note and we can chat.

Yes they would be. My work email is lworthey@uab.edu. Send me a note and we can chat.

We have some bandwidth and so I’m interested in expanding the nbr of ME/CFS patients whose genomes we analyze. If you have data and would be interested in signing up to our protocol (we have found interesting findings in some, but not all people) please reach out and I can explain. #ME/CFS #Genomics

Studying the Effect of Long COVID-19 Infection on Sleep Quality Using Wearable Health Devices: Observational Study Patients with COVID-19 have increased sleep disturbances and decreased sleep quality during and after the infection. The current published literature focuses mainly on qualitative analyses based on su...

pmc.ncbi.nlm.nih.gov/articles/PMC...

What types of variants are most commonly missed? #eshg2025

Choose Europe for Science: EU comes together to attract top research talent Research and innovation news alert: The European Union is stepping up to become the world’s most attractive destination for researchers and innovators.

Choose Europe for Science: EU comes together to attract top research talent research-and-innovation.ec.europa.eu/news/all-res...

Was not discussed in that context. Sorry! Sounds like lots of work in this context, so maybe someone to look up.?

AM: 1,715 combinations with nominally significant impacts were identified in UK Biobank study. Two clinically relevant examples of effect heterogeneity were seen: 1) BMA -T2D attenuates with age, 2) LDL cholesterol exacerbates with increased urate. Study just published #ESHG2025

AM: Resid-Strat, DR by G, DR by X, and Raw-Strat methods were all tested in term of impact on Type 1 error. Each method was found to be differentially affected by collider biases #ESHG2025

AM: discussing sources of collider bias - biases that occur when an exposure and outcome (or factors causing these) each influence a common third variable #ESHG2025

AM: Asking: In precision medicine in patients with cardiovascular disease - how can we systematically identify patients differentially effected by a broad range of clinical variables and risk modifiers #ESHG2025

Up now Alice Man discussing Identification of effect modifiers using a stratified mendelian randomization algorithmic framework #ESHG2025

CA: Collectively these measurements account for 70% of variation, allowing generation of an accurate time of day prediction that acts as a proxy for internal circadian time #ESHG2025

CA: Noted that effects were associated with multiple psychiatric disorders #ESHG2025

CA: Oscillation measure developed seen to be highly correlated with sleep questionnaire data and propensity to work night shifts due to sleep cycle shift #ESHG2025

CA: Proteomics explains 68% of circadian effect (despite being a smaller dataset), NMR 39%, Biochemistry 13%, and cell counts 6% #ESHG2025

CA: Studying which tissues show greatest circadian effect - variability with amplitude >0.2 and R2> 0.01 #ESHG2025

CA: Variety of plasma omics available for analysis. Time of day effect seen across all these datasets; to variable degrees when pre-regressed with age, PCs, fasting, and other technical covariates #ESHG2025

CA: Studied in the UK Biobank; identification of variance to be used to predict dysregulation/disease risk #ESHG2025

CA: circadian dysregulation alters the difference between external and internal time and can be measured by melatonin levels in the saliva #ESHG2025

Up now Clara Albinana on circadian dysregulation and disease risk in psychiatric and metabolic disorders #ESHG2025

LU: Studied incidence of T2D in individuals with melatonin prescription - individuals with the risk variant were seen to have higher risk of disease when supplemented with melatonin #ESHG2025

LU: Significant genetic correlation to short sleep. #ESHG2025

LU: Effect of MTNR1B variant effect varies over the day - assoc higher glucose in the am and lower in the pm - homozygous carriers showed 0.5mmol/l higher levels in the am than pm compared to non carriers - replicated to FinnGen, Estonian biobank #ESHG2025