Cell Symposia: Hallmarks of cancer

We're excited to host a distinguished lineup of speakers at @CellSymposia #CSHallmarks2026, including keynote speakers @johannajoyce.bsky.social & Faisal Mahmood @harvardmed.bsky.social. View the full speaker lineup: http://dlvr.it/TPbBpQ

Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below

Cell Symposia: Hallmarks of cancer

We're excited to host a distinguished lineup of speakers at @CellSymposia #CSHallmarks2026, including keynote speakers @johannajoyce.bsky.social & Faisal Mahmood @harvardmed.bsky.social. View the full speaker lineup: http://dlvr.it/TPbBpk

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

maybe the microbiota 😉 www.cell.com/cell/abstrac...

Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...

Thanks for highlighting our work!

Congrats, @catmphelps.bsky.social !

Catherine Phelps!

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

🔬 OBS Seminar

Shaping CD8+ T Cell Response Through Microbiota Metabolites
🗣️ Joseph Stevens @cincyresearch.bsky.social @cincykidsallergyim.bsky.social
🗣️@catmphelps.bsky.social @meisellab.bsky.social

🗓️ Thu, September 4th, 11 AM EDT, 3 pm GMT, 5 pm CET

👇 us02web.zoom.us/meeting/regi...

No strain, no formate gains - Nature Reviews Cancer In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

#ResearchHighlight

In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

👇

Congratulations to the team! Excited to see the study in print!!

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

congrats Alex!

Headshots of Dr. Marlies Meisel and Catherine Phelps side by side.

AAI Members in the News! For her grad thesis with Dr. Marlies Meisel at ‪@pittdeptofmed.bsky.social‬, ‪@catmphelps.bsky.social‬ showed how #exercise improves #cancer outcomes and enhances the response to #immunotherapy in mice by reshaping the gut #microbiome
🔗 www.medschool.pitt.edu/news/gut-mic...

Amazing! Congratulations Ruth

Thanks @nature.com for highlighting our recent study #exercise #microbiota #cancer

Exercise helps fight cancer – and we may finally know why Exercise seems to help prevent cancer and reduce the growth of tumours, and that protective effect may be due to the way working out changes the gut microbiome

Exercise seems to help prevent cancer and reduce the growth of tumours, but until now, we didn’t know why. The key seems to lie in the gut’s microbiome.

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...

📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P

thanks Ruth!

Gut Microbes Key to Understanding How Exercise Boosts Cancer Immunity Gut Microbes Key to Understanding How Exercise Boosts Cancer Immunity

www.upmc.com/media/news/0...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠

authors.elsevier.com/c/1lPCrL7PXu...

How exercise works through the gut microbiome to enhance response to cancer immunotherapy
www.cell.com/cell/fulltex... @cellpress.bsky.social

Very proud of first-author @catmphelps@bsky.social and other lab members!
Thanks to our collaborators @gottschalklab.bsky.social, zarourhm.bsky.social, especially @rh-lab.bsky.social many more (not on bsky)

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise Extends Life for People With Cancer, Study Shows The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.

A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM

Microbial molecule of ageing gut nudges blood stem cells towards cancer The risk of developing blood cancer increases with age. The finding that a molecule from gut bacteria plays a part points to new ways to intervene.

also a new N&V www.nature.com/articles/d41...