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Matt Donnelly

@mattdonnelly96.bsky.social

G3 MD/PhD student @UCSDMedSchool in Shadel Lab @salkinstitute | Interested in all things mitochondria, metabolism, and cardiovascular disease

32 Followers  |  75 Following  |  1 Posts  |  Joined: 13.11.2024  |  1.4463

Latest posts by mattdonnelly96.bsky.social on Bluesky

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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

congrats @delgoffelab.bsky.social !

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy: Cell Metabolism www.cell.com/cell-metabol...

29.01.2025 07:40 — 👍 23    🔁 7    💬 0    📌 0
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New: Sainz, Shadel et al. @salkinstitute.bsky.social investigate mitochondrial respiration-independent signaling induced by acute mtDNA depletion and uncover a role for FAM43A in a CHK2-dependent mitochondrial stress signaling pathway. https://buff.ly/40MBmIW
#mitochondria

27.01.2025 17:16 — 👍 15    🔁 4    💬 0    📌 1
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First post and first #fluorescencefriday has to go to a classic combination:
Outer mitochondrial membrane marker TOMM20(💙) and matrix protein HSP60 (❤️) in HEK cells!
#microscopy #cellbiology

21.12.2024 00:02 — 👍 16    🔁 1    💬 1    📌 0

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