Maëlle Bellec

Inject some #zebrafish into your timeline with our updated Starter Packs! 🧪

WomenInScience v1: go.bsky.app/4BegEjv
"" v2: go.bsky.app/VoebYrt
Resources: go.bsky.app/JcC5df3
Sr. Scientists & PIs v1: go.bsky.app/2cHYybY
"" v2: go.bsky.app/4zBuxAF
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"" v4: go.bsky.app/2c4WLQK

Very nice work congrats to all !

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...

Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...

Tissue-like multicellular development triggered by mechanical compression in archaea The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

RNA Salon in mRNA Translation

We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft)

Please RT
@goetheuni.bsky.social @cpi-exstra.bsky.social

Come and join us for the RMU RNA salon "Translation" in Frankfurt! Tuesday, April 1st 2025, 12:30 – 6:00 pm at Medical Campus Niederrad, Building 22 – HS22-2.

Please register here: bit.ly/13_RMU_RNA_S...

Thank you @rnasociety.bsky.social and #lexogen for funding!

We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org

This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.

Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!

🎓 Join us for our Spring School in Quantitative Biology: "Cell Dynamics in Developmental Systems"

✨ Featuring renowned speakers and hands-on workshops!

Learn more and register: www.edu.bio.ens.psl.eu/spip.php?art...

Here's a question to MS2 experts - do you know what is the shortests MCP peptide that can still bind to the MS2 stem-loop?
Did anyone look into that?

#RNASky #RNABiology #microscopy #single_molecule_imaging

Les riboswitches, des solutions innovantes pour les biotechnologies et le diagnostic médical | Canal U Présentation en motion design du projet ANR HELISWITCH porté par Marc Boudvillain

A bit of advertising for my sister's work 😉 : an educational video about riboswitches from Boudvillain's lab
www.canal-u.tv/chaines/cbm/...

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage found widespread in nature. Ribozyme cleavage generates distinct 2′,3′-phosphate and 5′-hydroxyl termini that r...

This week #ScienceMagazine Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies #URochesterResearch @urochester.bsky.social www.science.org/doi/10.1126/...

I am really enjoying the surge of people to bluesky but still kind of missing the VERY early career group of people! (Aging in academia is a funny thing) - I went ahead and made this starter pack go.bsky.app/Jq8YaQM - if you would like to be removed/added please let me know

Can I join 🙋‍♀️

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...

A toolkit for testing membrane localisation tags across species Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...

Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...

📢SAVE THE DATE
The 4th Molecular Biosystems Conference is set!

Plan to join us in southern Chile for insightful discussions on gene regulation & functional genomics #mbiosys25 🧬🔄

Stay tuned for more details!

🗓️Sep 29-Oct 3, 2025
📍Puerto Varas, Chile
🌐http://molbiosystems.com

Anyone knows of a genetic strategy to lower proteasome activity in a mouse ? For example by single allele loss of function of an essential proteasome subunit (which one ?) ?