Sharavan Vishaan V

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Nature research paper: Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

go.nature.com/479jKdH

Wellcome photography prize 2025 The Wellcome Photography Prize brings together visual stories of health, science and human experience.

Our new, free exhibition featuring shortlisted entries from the Wellcome Photography Prize opens tomorrow.

Stop by to experience stories of health, science and human experience captured in stunning photographs from around the world.

www.crick.ac.uk/whats-on/exh...

Thank you Anna Baulies Domènech and Abcam for inviting me to talk about my work at Cambridge.

🔬 I'm honoured to have been selected as a guest speaker.

#abcam #abscience #cambridge #science #research #immunology #metabolism #imaging #crick

You can read my work here: www.nature.com/articles/s41...

Exhausting bonding Nature Reviews Cancer, Published online: 02 July 2025; doi:10.1038/s41568-025-00849-0Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.

NEW content online!

Where is the best place to hold a scientific conference right now? An immigration crackdown makes the United States less attractive. These locations could steal its crown and make conferences more globally inclusive.

An immigration crackdown makes the United States less attractive. Where should you hold your next conference?

https://go.nature.com/407qJ2w

High-spatial-resolution mass spectrometry imaging of biological tissues using a microfluidic probe Nature Protocols, Published online: 12 June 2025; doi:10.1038/s41596-025-01188-yWe present a protocol for the design, fabrication and use of a microfluidic probe for nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) that achieves a spatial resolution of 8–10 µm and 10-fold improvement in experimental throughput.

New Article! High-spatial-resolution mass spectrometry imaging of biological tissues using a microfluidic probe

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance Lei et al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces cuproptosis by upregulating CTR1 and depleting mitochondrial glutathione. Furthermore, BACH1 downregulation confers radioresistance by upregulating MT1E/X-mediated cuproptosis defense. Correspondingly, copper-loaded copper ionophores restore RT sensitivity by enhancing cuproptosis, highlighting a therapeutic strategy to overcome tumor radioresistance.

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

The gut microbiome and cancer: from tumorigenesis to therapy - Nature Metabolism This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

REVIEW | M van Hul, P Cani et al. (UC Louvain):

This Review discusses the impact of the gut #microbiota on #cancer and on cancer therapy. 💊 🧫

FREE to read:

Machine learning algorithm brings long-read sequencing to the clinic SAVANA is a new tool designed for accurate detection of structural variations in clinical samples.

Long-read sequencing can reveal hidden cancer mutations, but existing tools often produce false positives.

SAVANA is a machine learning algorithm trained on cancer genomes, built to make analysis faster and clinically reliable.

@isidrolauscher.bsky.social

www.ebi.ac.uk/about/news/r...

#oncosky

Hello Brain! Explore the marvellous and mysterious world in your head.

Just one month left to visit #HelloBrain, our exhibition all about the marvellous and mysterious brain.

The exhibition will open to the public for the last time on Friday 20 June.
www.crick.ac.uk/whats-on/exh...

In a recent episode of @trialstribspod.bsky.social, Professor Kevin Harrington spoke with hosts @prof-nick-james.bsky.social and Dr @hoda-aty.bsky.social to discuss how #OncolyticViruses are used to infect and destroy cancer cells, while also triggering powerful immune responses.

Is the UK paying the price for world’s most expensive visas? | The Observer Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

As tighter immigration policies are announced today, scientists continue to stress the importance of attracting international talent.

Our director Paul Nurse spoke to the Observer about how this affects science in the UK:

observer.co.uk/news/politic...

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Nature reports on how researchers are studying why mitochondria are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics Nature Metabolism, Published online: 10 April 2025; doi:10.1038/s42255-025-01283-0Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

ICYMI:

Metabolism shapes life
EMBL Barcelona & @mpi-cbg.de researchers reveal how glycolysis drives early embryonic cell decisions.

The studies, published in Cell Stem Cell (@cp-cellstemcell.bsky.social), uncover the instructive potential of glycolysis.

www.embl.org/news/science...

Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies Li et al. analyze CD8+ T cells collected from HNSCC patients treated with neoadjuvant immunotherapies. They show that different combination immunotherapies modulate CD8+ T cell functional states through distinct transcriptional and clonal dynamics, providing insights that will guide the development of future innovative immune interventions in treating cancers.

Distinct CD8+ T cell dynamics associate with response to neoadjuvant cancer immunotherapies

Why an overreliance on AI-driven modelling is bad for science Nature - Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.

Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good

https://go.nature.com/42nGQt6

Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids Wang et al. advance bacteria-based metabolic therapy by developing DL@SFEc+ through dual-selection evolution. The evolved SFEc+ significantly enhances CySS uptake and desulfhydrase activity. Combined with DMXAA-loaded liposome, the DL@SFEc+ disrupts tumor nutrient influx and redox balance, showcasing effective antitumor capabilities and stability across various tumor models.

Online now: Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids

A saliva test, which analyses men's DNA, could be used in helping to identify those at greater risk of #ProstateCancer, according to a new study led by the ICR's Professor Ros Eeles.

Full story ⬇️
www.icr.ac.uk/about-us/icr...

Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells - Nature Communications Lactobacilli are a principal microbial constituent in the human uterine cervix and vagina. Here, authors identify the stem cells in the human uterine cervix and the role of Lactobacilli metabolite in cervical stem cells and cervical cancers.

Exciting new research in Nature Communications shows that D-lactic acid inhibits the growth of both normal and precancerous cervical organoids, while L-lactic acid has no effect. Check out the full article here:

🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org

We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...

Moonlighting functions of glucose metabolic enzymes and metabolites in cancer Nature Reviews Cancer, Published online: 02 April 2025; doi:10.1038/s41568-025-00800-3Glucose metabolic enzymes and their metabolites provide cells with energy and building blocks for the synthesis of macromolecules. However, it has become clear that they also have non-canonical functions, which modulate various cellular activities. In this Review, Guo et al. discuss how these moonlighting functions can help drive cancer progression.

NEW content online!

✨New issue! ✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Macrophages, #Tcells, #Circadian biology, the effects of #Diet on #Body and #Brain - and many more topics!

www.nature.com/natmetab/vol...

Aldolase A: the broker of glycolysis - Nature Metabolism

NEWS&VIEWS | LM Nascentes Melo, F Cansiz & A Tasdogan (DKTK, DE)

#AldolaseA inhibition in cancer cells turns #glycolysis into an ATP-consuming process. Imbalanced glycolysis could overcome the intrinsic metabolic plasticity of #cancer cells.

https://bit.ly/41Al0SQ

Dynamic STING repression orchestrates immune cell development and function Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn

Segger logo

Message passing intuition behind the segger’s link-prediction model and the network architecture

1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...

Giving blood linked to lower risk of pre-cancer gene Frequent donors were more likely to have different genetic changes in their blood stem cells, scientists found.

In case you missed our story from earlier this week, you can read about the newly discovered potential link between giving blood and certain beneficial genetic changes in this BBC News article covering the topic.

www.bbc.co.uk/news/article...