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Michael Kugler

@michaelkugler.bsky.social

Postdoctoral researcher | Hopfner lab | Gene Center #StructuralBiology #CryoEM #InnateImmunity

47 Followers  |  100 Following  |  1 Posts  |  Joined: 24.11.2024  |  1.5046

Latest posts by michaelkugler.bsky.social on Bluesky

Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1

22.11.2024 08:10 β€” πŸ‘ 19    πŸ” 9    πŸ’¬ 0    πŸ“Œ 4
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Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social πŸ§¬πŸ”¨
www.biorxiv.org/content/10.1...

17.03.2025 09:43 β€” πŸ‘ 52    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1
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Join us in our next #MunichRNA19F!
πŸ“ @mpibiochem.bsky.social
πŸ“… 19/02/2025

We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian.

Don't miss it! πŸ§¬πŸ˜€

29.01.2025 12:00 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1

Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and Katja Lammens in @hopfnerlab.bsky.social at @genecenter-lmu.bsky.social. Now online at @naturecomms.bsky.social.

03.12.2024 20:00 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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