Andrea Cosentino

Beyond polyA: scalable single-cell total RNA-seq unifies coding and non-coding transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.08.669394v1

the treasure trove of all sequencing datasets

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...

Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

www.science.org/doi/10.1126/...

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

Environmental stress drives clearance of a persistent enteric virus in mice @natmicrobiol.nature.com @cadwelllab.bsky.social www.nature.com/articles/s41...

Pan-viral ORFs discovery using massively parallel ribosome profiling @science.org @shiraweingarten.bsky.social @sabetilab.bsky.social @pardissabeti.bsky.social
www.science.org/doi/10.1126/...

@cellcellpress.bsky.social preview:
Reaching for more: How reproduction transforms the maternal intestine
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

Taurine from tumor niche drives glycolysis to promote leukeamogenesis @nature.com @jeevishabajaj.bsky.social
www.nature.com/articles/s41...

Thanks a lot for what you are doing! I always find so many interesting readings posted from your profile 🙏

This is so cool!

Why test #celltherapies one-by-one when you can use multiplexed #SynBio #proteinengineering & #ML to design, measure & track them at scale?

The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!

More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏

Reprogramming site-specific retrotransposon activity to new DNA sites @nature.com
www.nature.com/articles/s41...

DNA-guided transcription factor interactions extend human gene regulatory code @nature.com
www.nature.com/articles/s41...

The joy of learning:
"In the early 1980s, it was discovered that 1 mutation in the fruit fly genome could specifically activate all copies of a retrovirus-like element called Gypsy in the female germline. The site of the mutations that made these Gypsies "dance" was thus called the flamenco locus."

Scalable and cost-efficient custom gene library assembly from oligopools https://www.biorxiv.org/content/10.1101/2025.03.22.644747v1

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

Exciting discovery by Svensson lab and collaborators @stanfordmedicine.bsky.social, computational discovery of 2500 new bioactive peptides, including 12-mer named BRP that reduces food intake leading to weight loss w/o nausea in mice!

www.nature.com/articles/s41...

Structural mechanism of LINE-1 target-primed reverse transcription Long interspersed element-1 (LINE-1) retrotransposons are the only active autonomous transposable elements in humans. They propagate by reverse transcribing their mRNA into new genomic locations by a ...

Congrats @automnenine.bsky.social and @kellythd-nguyen.bsky.social !

www.science.org/doi/10.1126/...

Vitamin C directly modifies lysine residues through vitcylation, regulating STAT1 signaling and enhancing anti-tumor immune responses by preventing STAT1 dephosphorylation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...

Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades
www.nature.com/articles/s41...

Studying outliers is always super interesting! What a fascinating combination of genetic variants, epigenetic phenotypes, microbiome compositions... I would also really love to hear the story of her life. Amazing work!

The Multiomics Blueprint of Extreme Human Lifespan https://www.biorxiv.org/content/10.1101/2025.02.24.639740v1

Studying Epigenetic: my understanding is that CpG sites are converted to 5mC-G by default, and 5mC is more prone to transition into T (without methylation, BER would repair the deamination). So, CpG islands are conserved because they are often hypomethylated. Is this correct in principle?

A swapped genetic code prevents viral infections and gene transfer - Nature A study details the creation of an Escherichia coli genetically recoded organism that is resistant to viral infection, and describes a further modification that keeps the organism and its genetic info...

You have “space” to insert some non canonical AA into proteins. And other elegant application as viral resistance -> www.nature.com/articles/s41...

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

scary but fascinating - cells have a degradation pathway that hunts down C-terminal scars (amides!) on damaged proteins. just wow. chemical biology plus CRISPR at its best. big congrats to all authors!

www.nature.com/articles/s41...

This is the letter written by Albert Camus to his schoolteacher, Louis Germaine, after receiving the Nobel Prize in Literature Here is the full text - translated into English: 19 November 1957 Dear Monsieur Germain, I let the commotion around me these days subside a bit before speaking to you from the bottom of my heart. I have just been given far too great an honour, one I neither sought nor solicited. But when I heard the news, my first thought, after my mother, was of you. Without you, without the affectionate hand you extended to the small poor child that I was, without your teaching and example, none of all this would have happened. I don’t make too much of this sort of honour. But at least it gives me the opportunity to tell you what you have been and still are for me, and to assure you that your efforts, your work, and the generous heart you put into it still live in one of your little schoolboys who, despite the years, has never stopped being your grateful pupil. I embrace you with all my heart. Albert Camus

January is #MentoringMonth a time to reflect on the importance of mentor-mentee relationships

And a good moment to share this beautiful letter written by Albert Camus to his teacher, after receiving the Nobel Prize

You can't underestimate the impact of a great #teacher or #mentor!

#ThankAMentor 🙏

Enhancer scrambling strategy

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...

Credit is infinitely divisible in academia: the more authors on a paper, the merrier. Middle authors contribute so much and share in the credit, while that doesn’t take away any of the credit from the lead contributors.

George and his team members are undoubtedly one of the groups that make HMS an extraordinary place.