Sean Fanning

🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá ‪@estebanezlab.bsky.social ‬@ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋

I know & trust that NIH staff will get this round of reviews done. Yet having done my own CSR reviews 'for nothing' & with my own R01 sitting unreviewed now, working on another NIH grant has never felt so painful and futile. A quiet impact on science, perhaps, robbing the joy from looking ahead.

Democracy in action, Illinois.

Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.

Just wrapped up my medical school teaching for the year. I happened to have an exceptionally awesome group of M1s. I’m excited to see where they’ll go from here!

Meanwhile, when the dean utters his refrain, “Thank you for all your hard work,” the faculty will simply hear, “Sorry, we have no money to pay you.”

RFK Jr. and Trump tell us they want to Make America Healthy Again.

Great slogan. I agree. Unfortunately, they are doing the exact opposite.

Vaccines work. They are safe. They save lives.

No more conspiracy theories.  Kennedy must resign.

Fanning Lab BBQ 2025! Another good year in the books thanks to this exceptional group! Also, they wanted me to make ribs and brisket, they know I look for any excuse to do a cook.

You all were well represented!

Finally, I really enjoyed the opportunity to explore San Francisco more. Alcatraz was an eye opening experience, being a Chicago guy, I had to find the place that kept Capone.

I was also fortunate to have one of my proposed sessions take place on the latest in hormone-dependent cancers, which featured a fantastic story from Dan Frigo on metabolism in prostate cancer.

I had a wonderful time at Endo2025, catching up with great colleagues doing fantastic and important work in endocrinology. I particularly enjoyed chairing the session on Nuclear Receptor Structural Biology where @dougkojetin.bsky.social gave a powerhouse performance! 1/3

New review from us on radiation in #lobular breast cancer!
www.nature.com/articles/s41...

Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data?

led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n

Bronze sculpture of a T-cell attacking a cancer cell.

Bronze sculpture of a T-cell attacking a cancer cell.

Finished another bronze of a T-cell attacking a cancer cell. This one is heading to Max Krummel at UCSF, who did some of the early studies on CTLA4 immunotherapy. #sciart.

Very proud of Sofia for successfully defending her Master’s thesis today!! She’s starting her PhD in biomedicine at UMiami next year. Can’t wait to see what she’ll accomplish! I’m a proud PI!

Thinking about a move from academia to industry? Look before you leap - Nature Biotechnology To those considering a change in careers from academia to the pharmaceutical industry, here are the keys to a successful transition.

A careers feature in Nature Biotechnology provides some keys to a successful transition from a career in academia to one in industry. #Academicsky 🧪

Colorectal cancer treated with cholesterol inhibitor in U. of I. study | School of Molecular & Cellular Biology | Illinois University of Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.

#Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.

The study was published in Nature Chemical Biology:

go.mcb.illinois.edu/623
@nelsonlab.bsky.social

We did a thing w @jostrander.bsky.social!
Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n

CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1

Cool stuff 🎉👏 @mjsikora.bsky.social
@jostrander.bsky.social #bcsm #lobular 🧪🧬

Duckworth statement on Trump’s strikes against Iran nuclear sites.

Duckworth statement on Trump’s strikes against Iran nuclear sites.

Trump bombing Iran was illegal and unjustified.

I ran for Congress to make sure our leaders consider the true costs of war.

And I will be in the Senate, standing on my titanium legs, demanding answers from Trump.

My statement:

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM

"zimislecel can restore physiologic islet function"

Reference
www.nejm.org/doi/full/10....

Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity https://www.biorxiv.org/content/10.1101/2025.06.16.659976v1

HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer Endocrine resistance is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancer, often leading to disease recurrence and metastasis. 3β-Hydroxysteroid dehydrogenase 1 (3βH...

Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

What an amazing time to be a biomedical scientist.

www.nejm.org/doi/abs/10.1...

Congratulations!!!! I’m excited to read and share this important work!!

Today I’m leading 152 House Democrats in challenging Trump's devastating cuts to life-saving NIH research grants. Congress—not Trump—controls federal spending.

Trump must do his job, “faithfully execute” the laws and stop violating the Constitution to undercut public health.

Congrats to Team Bitler—Drs. Bitler, Corr, Sikora, Clauset, and many others—2025 CU ASPIRE Awardees🎉Their SPORE effort to advance ovarian cancer care with novel therapies & population science. #OvarianCancer #CUAnschutz @uccc-gorg.bsky.social‬ @mjsikora.bsky.social View details here: Bit.ly/4mWBRsO

The Illinois General Assembly and I are working to make life more affordable for working families.

Unlike the Trump administration, we're balancing a budget while maintaining programs our people rely on — and we're investing in our children and building them a brighter future.

BREAKING: A federal judge reversed National Institutes of Health's terminations of hundreds of critical research grants that were canceled because of their alleged connection to disfavored topics, including diversity, equity, inclusion, and gender identity.

This is a major win for public health.

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu

and read about it here->
www.nature.com/articles/s41...