Tommaso Marchetti

Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model Primary hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome. In familial HLH, loss-of-function mutations in genes such as Prf1 disrupt perforin-dependent cytolysis, leading to s...

The main part of my PhD work is published!

We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.

Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable The Nobel committee has been unable to reach a winner of this year’s prize for medicine who is “living his best life” on an “off the grid” hiking foray. Fred Ramsdell shared Monday’s prestigious prize with Mary Brunkow of Seattle, Washington and Shimon Sakaguchi of Osaka University in Japan for their discoveries related to the functioning of the immune system. Continue reading...

Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid

A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...

The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!

We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!

www.nature.com/articles/s41...

A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...

How did Cell, Nature & Science become the 3 hottest journals in biomedical research? You could call it 'The Curious Case of Benjamin Lewin’ & it's told in today's episode of the Night Science podcast with Keith Yamamoto (@kryamamoto.bsky.social ; starts at 15:00) @nightsciencepod.bsky.social ⬇️

Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation https://www.biorxiv.org/content/10.1101/2024.08.12.607544v1 Haemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory disorder often drive

Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation https://www.biorxiv.org/content/10.1101/2024.08.12.607544v1

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66 | Michael Fischbach and the scientific decision tree Podcast Episode · Night Science · 11/25/2024 · 51m

Too often we spend only two weeks choosing a problem and then many years trying to solve it, but this limits our potential impact. For more listen to this really interesting @nightsciencepod.bsky.social episode!
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...

"We love interdisciplinary work! But..."

Vive La France! 🇫🇷

So much new on #longcovid. I've tried to pull it all together in a new Ground Truths
erictopol.substack.com/p/lighting-u...