Ilaria Panzeri

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Cuts to NIH grants don’t just affect clinicians and researchers– they affect patients, too. A new study shows that cancelled NIH funding led to the termination of 383 clinical trials, affecting more than 74,000 participants. Learn more: https://bit.ly/411zjk0
#Fight4Hematology

Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice - Nature Communications KRAB-zinc finger proteins repress retrotransposons and rapidly evolve in mammals. Here, the authors show that ERV insertions drive the emergence and diversification of new KZFP genes in mice, revealin...

Having a lot of fun at #EMBOMobileGenome 😃
Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!!

…and I’m currently on the job market looking for a new scientific home!

www.nature.com/articles/s41...

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?

rdcu.be/eN1jm

Graduate School Learn more about at Van Andel Institute. Explore our in-depth resources and latest articles.

Van Andel Institute PhD program- App Deadline soon

Innovative curriculum/personalized academic support/generous financial support: $44,635 stipend, tuition waiver, health insurance coverage, laptop computer, $2,500/year for scientific conferences, relocation allowance.

www.vai.org/graduate-sch...

One of the neatest pieces of Science I've seen in a while.

Incredibly cool biology (no spoilers, go read it), a question tackled from every angle, 3 (three!) models, and paper that reads better than a novel

Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements | PNAS The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich regions of DNA with a higher-than-expected occurrence of CpG din...

'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...

Programmable promoter editing for precise control of transgene expression - @mitcheme.bsky.social @mitdeptofbe.bsky.social go.nature.com/4h9wlR1

(1/4) New Pre-print! 🌟
Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.

Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma - Nature Cell Biology Mohri et al. show that, in response to genotoxic stress, melanocyte stem cells undergo senescence-associated differentiation, causing their depletion and protecting them against melanomagenesis. This process is suppressed by carcinogens.

Very interesting and elegant paper:
McSCs undergo seno-differentiation in response to DNA DSBs resulting in hair greying, and effectively protecting against melanoma. Conversely, carcinogens can suppress McSC seno-differentiation promoting self-renewal.
www.nature.com/articles/s41...

This is figure 1, which shows DNA methylation-based classification of acute leukemia.

A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪

#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Scientists make most authentic kidney replicas so far Lab-grown organoids reproduce some of a kidney’s internal structure and function

Lab-grown organoids reproduce some of a kidney’s internal structure and function. https://scim.ag/4n0YH26

Surprising?

Delays, uncertainty plague NSF fellowship for graduate students After an unusual award process this year, applicants for next year are waiting for overdue guidelines

"We are so very late that many students will not be able to apply this year."

My latest story—about frustration over delays for NSF's graduate research fellowship program. #NSFGRFP #GradSchool @science.org

www.science.org/content/arti...

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Congratulations!! 👏🏻👏🏻

Unmasked: transposable elements as drivers and targets in cancer. #TransposableElements #TEs #CancerDrivers @cp-trendsgenetics.bsky.social
www.cell.com/trends/genet...

Survey the landscape of healthy human immune cells from childhood to adulthood with the Human Immune Health Atlas!

This RNA-seq data features over 1.8M+ cells obtained from 108 healthy pediatric, adult, and senior donors. apps.allenimmunology.org/aifi/resourc...

#OpenScienceWeek

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...

The Many Faces of Cancer Evolution Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to an…

🚀 WE'RE BACK! "The Many Faces of Cancer Evolution" is coming back to Rimini on May 27-29, 2026! meetings.embo.org/event/26-can... Join me, Luca @magnanilab.bsky.social , Celine Vallot, and Samra @turajliclab.bsky.social for 3 days of amazing science on the beach! @embo.org meeting #cancer 👇👇

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth

go.nature.com/4lZtawb

CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...

(1/4) New preprint from the lab!
The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. www.biorxiv.org/content/10.1...

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

One mother for two species via obligate cross-species cloning in ants Nature - In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from...

Pretty amazing observation in nature rdcu.be/eEebw

Beneath the surface of the sum When genetic interactions matter and when they don't

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

Science Fellows

Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!

stanfordsciencefellows.stanford.edu