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Guillaume Bossis

@guillaumebo6.bsky.social

Biologist, PI @igmm-montpel.bsky.social @cnrs.bsky.social, Montpellier, France. Acute Myeloid Leukemia and SUMOylation https://www.igmm.cnrs.fr/en/team/sumoaml/

439 Followers  |  339 Following  |  11 Posts  |  Joined: 13.11.2024  |  1.851

Latest posts by guillaumebo6.bsky.social on Bluesky

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Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.

New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer

25.09.2025 11:59 β€” πŸ‘ 19    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1
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πŸ”₯ The #EMBOSUMO workshop kicks off TODAY! πŸŽ‰ Thanks @embo.org @biologists.bsky.social @proteocure.bsky.social @sebiology.bsky.social @newphyt.bsky.social @umontpellier.bsky.social @occitanie.bsky.social for their support. More info: meetings.embo.org/event/25-sum...

22.09.2025 07:45 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 3
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Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...

03.09.2025 05:02 β€” πŸ‘ 47    πŸ” 22    πŸ’¬ 5    πŸ“Œ 0
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Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation www.biorxiv.org/content/10.1... @embl.org

18.08.2025 12:39 β€” πŸ‘ 19    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
Targeting SUMOylation triggers interferon-ß-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia Abstract. Natural Killer (NK) cells can play a significant role in the anti-tumoral immune response. In patients with Acute Myeloid Leukemia (AML), NK cells are however often found in low numbers and ...

πŸ“£ Happy to share our last publication on SUMOylation and Natural Killers in AML. aacrjournals.org/mct/article-...

16.07.2025 08:15 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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πŸ“’ The 21st Annual Meeting of CancΓ©ropΓ΄le GSO is back!
πŸ—“οΈ November 26–28, 2025 in Agen

Join us around cancer research !

Abstract submissions:
Oral: until September 19
Posters: until October 3

πŸ‘‰Registration: until October 31
More info: kgso.fr/events/21st-...

30.06.2025 22:05 β€” πŸ‘ 0    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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πŸ“£ We are recruiting new group leaders in Innovative Biology!

RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology

Application and information ⬇️
application.igmm.cnrs.fr

@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

28.05.2025 12:12 β€” πŸ‘ 36    πŸ” 53    πŸ’¬ 3    πŸ“Œ 2
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SUMOylation: From discovery to translation Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …

Learn more about SUMOylation at EMBO Workshop "SUMOylation: From discovery to translation" in La Grande Motte, France, 22–25 September 2025

Early Bird Registration/Abstract Submission by 1 May
Late Bird Registration by 1 June

meetings.embo.org/event/25-sum...
#EMBOsumoylation #EMBOevents πŸ§ͺ

25.04.2025 07:02 β€” πŸ‘ 11    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow. Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...

New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.

www.biorxiv.org/content/10.1...

28.04.2025 07:55 β€” πŸ‘ 21    πŸ” 10    πŸ’¬ 1    πŸ“Œ 2

Hello Ubiquitin-like fans, check this πŸ‘‡πŸ‘‡πŸ‘‡
Early Bird Registration Deadline
πŸ—“οΈ 1 May 2025
Abstract Submission Deadline
πŸ—“οΈ 1 May 2025
Don't miss the date!
@proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social
#ubiquitin #SUMO #EMBO Workshop
meetings.embo.org/event/25-sum...

14.04.2025 10:10 β€” πŸ‘ 9    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Rendez vous Γ  18h, Place de la ComΓ©die #StandUpForScience #Montpellier @standupforscifr.bsky.social

03.04.2025 13:28 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Global analysis of protein turnover dynamics in single cells The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

πŸš€ Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

31.03.2025 15:11 β€” πŸ‘ 46    πŸ” 12    πŸ’¬ 2    πŸ“Œ 2
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Diplomatic row erupts after French researcher expelled from US for expressing 'a personal opinion' on Trump A diplomatic row has erupted between France and the US after a French researcher was expelled from the country for expressing "a personal opinion" on Trump.

🚨🚨 This is a very clear signal to all us researcher to stay off the US for the next three years: A French academic, who was on assignment from the CNRS, was detained by officers & later deported after landing at George Bush International Airport ahead of conference.🧡
www.lbc.co.uk/world-news/d...

20.03.2025 06:20 β€” πŸ‘ 385    πŸ” 224    πŸ’¬ 38    πŸ“Œ 28
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SUMOylation: From discovery to translation Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …

Reminder: join us for the @embo.org Workshop SUMOylation: from discovery to translation, Sept 22-25 in La Grande Motte. With the support of @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social. Don't wait to register
meetings.embo.org/event/25-sum...

14.03.2025 11:19 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1
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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin etΒ al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social

11.03.2025 13:53 β€” πŸ‘ 37    πŸ” 16    πŸ’¬ 3    πŸ“Œ 0
Image of people at Stand Up for Science today in front of the Lincoln Memorial, with a person holding a sign that says "Musk reverses scientific progress"

Image of people at Stand Up for Science today in front of the Lincoln Memorial, with a person holding a sign that says "Musk reverses scientific progress"

Image of people in front of the washington monument and the reflecting pool at the lincoln memorial.

Image of people in front of the washington monument and the reflecting pool at the lincoln memorial.

Image of people at the Stand Up for Science events

Image of people at the Stand Up for Science events

Today, more than 10,000 people across the United States and beyond Stood Up for Science. I feel deeply humbled, inspired, and energizedβ€”our work is far from over, but witnessing so many people unite to champion science and the hope it brings is truly incredible.

08.03.2025 04:13 β€” πŸ‘ 728    πŸ” 114    πŸ’¬ 7    πŸ“Œ 6

Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain

08.03.2025 06:56 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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We keep standing up for Sciences in Montpellier @standupforscifr.bsky.social

07.03.2025 18:36 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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#StandUpForScience Montpellier @standupforscifr.bsky.social

07.03.2025 15:51 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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UniversitΓ© de Montpellier, Campus Triolet

07.03.2025 15:12 β€” πŸ‘ 95    πŸ” 18    πŸ’¬ 0    πŸ“Œ 1
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Stand up for Science in Montpellier!
@standupforscifr.bsky.social @standupforscience.bsky.social @cnrsbiologie.bsky.social
@biolum-montpellier.bsky.social
@cnrsoccitanieest.bsky.social

07.03.2025 14:38 β€” πŸ‘ 33    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0
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#StandUpForScience Montpellier, France @standupforscifr.bsky.social @standupforscience.bsky.social

07.03.2025 13:22 β€” πŸ‘ 132    πŸ” 35    πŸ’¬ 2    πŸ“Œ 4
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My favorite thing about the @standupforscience.bsky.social map is that the French people obviously maintain their solidarity and know the history of our joint venture in revolution. Those in power in the U.S. would have us forget this, but I ’ll be Santa Fe tomorrow, how’s about you?

06.03.2025 15:19 β€” πŸ‘ 401    πŸ” 93    πŸ’¬ 18    πŸ“Œ 7
Tous les évènements | Stand Up For Science France

Les rassemblements, dΓ©bats, discussions ouvertes et marches s'organisent vite :

- Retrouvez toutes les informations des initiatives existantes
- Inscrivez les nouvelles en moins de 2 min

standupforscience.fr/tous-les-eve...

06.03.2025 08:02 β€” πŸ‘ 14    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1
J.D. Vance | The Universities are the Enemy | National Conservatism Conference II
YouTube video by National Conservatism J.D. Vance | The Universities are the Enemy | National Conservatism Conference II

"The universities control the knowledge in our society (...) We have to agressivly attack the universities (...). Fundamental lies that feminism is liberating (...) There is wisdom in what Nixon said, the professors are the enemy "

bryanalexander.org/politics/the...

www.youtube.com/watch?v=0FR6...

03.03.2025 10:22 β€” πŸ‘ 673    πŸ” 481    πŸ’¬ 85    πŸ“Œ 209
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Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

https://go.nature.com/4kd1vIu

25.02.2025 21:53 β€” πŸ‘ 677    πŸ” 286    πŸ’¬ 8    πŸ“Œ 26
This is a flyer for stand up for science showing france in blue and the stand up for science logo in red (like a flag) and the date of march seven. It says in french "science is a common goo"

This is a flyer for stand up for science showing france in blue and the stand up for science logo in red (like a flag) and the date of march seven. It says in french "science is a common goo"

On March 7, let's stand up for science! πŸ”¬βœŠ In solidarity with Stand Up For Science US (@standupforscience.bsky.social) and in response to threats against scientific institutions, actions will take place in every university city in France. Info & registration πŸ‘‰ standupforscience.fr

23.02.2025 17:54 β€” πŸ‘ 109    πŸ” 56    πŸ’¬ 3    πŸ“Œ 7

Message to our European colleagues : we can help you create events in your country / cities.

23.02.2025 17:55 β€” πŸ‘ 32    πŸ” 20    πŸ’¬ 1    πŸ“Œ 0
This is a venn diagram showing how 69 Trump actions map onto domains covering: undermining democratic institutions; suppressing dissent and media; dismantling social protections; attacking science and education; destabilising the global order. A table version is available here https://docs.google.com/spreadsheets/d/1LZN7QnbSyFfUZJG8Sn1MWpK0VnfBtb0OSyZ1jxP3xBk/edit?usp=sharing

This is a venn diagram showing how 69 Trump actions map onto domains covering: undermining democratic institutions; suppressing dissent and media; dismantling social protections; attacking science and education; destabilising the global order. A table version is available here https://docs.google.com/spreadsheets/d/1LZN7QnbSyFfUZJG8Sn1MWpK0VnfBtb0OSyZ1jxP3xBk/edit?usp=sharing

🧡"So this is how liberty dies..."

Trump’s first 3 weeks have been a relentless flood of actions. It's incredibly hard to keep up.

I’ve gone through 69 actions & mapped out the pattern - showing how they fall within 5 broad domains consistent with authoritarian states 1/9

13.02.2025 11:37 β€” πŸ‘ 10056    πŸ” 5814    πŸ’¬ 491    πŸ“Œ 590
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!THREE OPPORTUNITIES TO JOIN US!

We are looking for 3 (!!!) PhD students interested in:
How Metabolism affects Genome Regulation.

Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow.

More info:
2 x experimental: www.nuclear-dn.eu
1 x computational: www.hubmol.eu

12.02.2025 15:34 β€” πŸ‘ 8    πŸ” 11    πŸ’¬ 0    πŸ“Œ 1

@guillaumebo6 is following 20 prominent accounts