Matt Sapio

Awesome 😎

Is this too Lisa Frank for a journal cover? #MicroscopyMonday

I tried to look what this news is but didn’t see it. Can you share?

Thanks! Helpful.

NIH scientists pioneer promising treatment for intractable cancer pain RTX is a non-addictive pain therapy derived from a cactus-like plant.

A rare opportunity to have our work highlighted by NIH.
www.nih.gov/news-events/...

Treatment of Intractable Cancer Pain with Resiniferatoxin — An Interim Study A substantial number of patients with advanced cancer suffer from refractory pain despite comprehensive medical management. In this article, we evaluate a nonopioid analgesic, resiniferatoxin (RTX)...

This study has been going on for the entirety of my time at NIH. It is incredibly gratifying to finally see it published to have something to point to for the work that has been put into this, both on this specific project and in making RTX a medicine more broadly.

evidence.nejm.org/doi/full/10....

That’s cool! Where is it?

This is quite interesting. We also observed this in our study of ADORA3 expression in human DRG. Beautiful staining in this one.

Relatable

This is really nice! What is it?

PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co

A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...

Wait but you’re not verified??

Figure 2. Larger protein language models access broader swaths of sequence space, enabling generation of more diverse sequences.

ProGen3 is out and shows a cool result: as PLMs get larger, they can successfully generate across a broader cross-section of the protein fold space www.profluent.bio/showcase/pro...

From @alexchesler.bsky.social lab!!

i mean it's one five-minute task, michael. how long could it take to get started on it, ten days?

“Currently, onerous conflict of interest rules and other forces inhibits an easy exchange between academia-biotech-private equity...”

This seems like something to contemplate. It never made sense to me that we can’t differentiate conflict of interest from healthy convergence of interest.

I’m inspired 😁

Maybe an example would help. Alphafold predicts protein structures and has been very helpful in drug design.

😍

Carriers of SCN9A variants linked to inherited and acquired pain syndromes show no alteration in the prevalence of pain or analgesic usage in the UK Biobank cohort The voltage-gated sodium channel NaV1.7, encoded by the SCN9A gene, is integral to nociceptor excitability and pain sensation. Multiple gain-of-function SCN9A variants have been reported to cause auto...

I'm shook!! www.medrxiv.org/content/10.1...

Choroid plexus is often lost during tissue sectioning and overall anatomy can be difficult if not impossible to reconstruct. Here we observe the vascular anatomy of human choroid plexus as if through a jeweler’s loupe. Sample courtesy of Matthew Schrag and Neil Dani. #FluorescenceFriday

Incredible!

Mapping brain development A new study provides a two-dimensional gene expression map during early brain development.

A new 2D gene expression map of the mouse brain during early development.

Your microscopy is so beautiful! Looks like another album cover 😁

That was such a legendary post. I miss horse ebooks.

Going all the way back. Sounds interesting

Welcome

This is inspiring

Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...

BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social

Congratulations!