Nate

Many condensates can be described as active soft materials that generate molecular fluxes. Here we develop a new #nonequilibrium approach (TRACE) to study molecular transport through condensates! Work led by Yashraj Wani!!

www.biorxiv.org/content/10.6...

How does protein folding change inside biomolecular condensates?

Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

If you like our article, please also consider reading the great work done by experimental colleagues in the field on this topic, including:

doi.org/10.1073/pnas... from @lek-lab.bsky.social

doi.org/10.1073/pnas... from the Sosnick Group

doi.org/10.1038/s415... from the JD Gross Lab

2. (cont) changes with contact rearrangements to co-condensate proteins.
3. Folding landscapes are dually sequence-dependent, informed by both the folded domain and co-condensate proteins.

(3/4)

Key aspects of our framework include that:

1. Condensates tune protein structure through both multivalent interactions (promotes unfolding) and crowding (promotes folding).
2. Kinetic transitions in protein structures are frustrated within condensates due to coupled conformational

(2/4)

I am very excited to share our pre-print that was just released on the bioRxiv entitled "Biomolecular Condensates Dictate the Folding Landscape of Proteins" doi.org/10.64898/202...

Very grateful for @jerelleaj.bsky.social and the members of the Joseph Group for their support on this project! (1/4)

Biomolecular Condensates Dictate the Folding Landscape of Proteins https://www.biorxiv.org/content/10.64898/2026.01.12.699095v1

Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social.

#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction

authors.elsevier.com/sd/article/S...