Nanobodies to the rescue!

So cool!

Cool!

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation - Nature Communications Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...

😂

Oooh, I want one!!

Selection of nanobodies against liponanoparticle-embedded membrane proteins by yeast surface display Single-domain antibodies, known as nanobodies (Nbs), are widely used in structural biology, therapeutics, and as molecular probes in biology and biotechnology. Nbs towards soluble proteins are routine...

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Excited to share our latest preprint!

www.biorxiv.org/content/10.1...

We developed a method to generate high-affinity binders against membrane proteins in their native-like environment!

🧪 #MembraneProteins #Nanobodies

Nice resource!

Wow! So much food for thought

Interesting!

A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools

A call for built-in biosecurity safeguards for generative AI tools go.nature.com/3GIpTlR

Very important

Oh this is some food for thought...

This is figure 1, which shows illustrating mechanisms, metrics and modifiers through the example of IBD.

A Review in Nature Medicine summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field. go.nature.com/42LUmrU 🔒

Information storage across a microbial community using universal RNA barcoding - Nature Biotechnology Barcoding microbial ribosomal RNA creates a recording of gene transfer events without requiring translation.

Fresh in @NatureBiotech! We developed a synthetic biology tool for tracking gene transfer in microbial communities and applied it to study plasmid hosts in a wastewater microbiome. Awesome collab with James Chappell & @joffsilberg.bsky.social and incredible students. www.nature.com/articles/s41...

Cool!

Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...

Hugely significant finding for contact site research - can’t wait to read properly!
www.nature.com/articles/s41...

I also wanted to access but it is restricted

Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagg...

The spread of highly pathogenic avian influenza in U.S. dairy cattle can be traced to a single spillover event from a wild bird, researchers report in Science, raising concern over growing pandemic risks as the virus evolves and leaps between species. scim.ag/4jIRUrO

The well plate reader sounds very interesting

GitHub - oxpig/ANARCII: A language model suite for numbering antigen receptor sequences. A language model suite for numbering antigen receptor sequences. - oxpig/ANARCII

We have released the successor to ANARCI - ANARCII - a suite of Seq2Seq language models trained to number antibody (or TCR) sequences!

Read the paper: biorxiv.org/content/10.1...

Play with the webtool: opig.stats.ox.ac.uk/webapps/sabd...

Documentation and codebase: github.com/oxpig/ANARCII

AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized... Antibodies have become an important class of therapeutic agents to treat human diseases. To accelerate therapeutic antibody discovery, computational methods, especially machine learning, have...

“AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions”

arxiv.org/abs/2306.03329

Wow! Cool!

Wow!

Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...

NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth

Interesting!

Interesting

Cool!

Protein Carrier Adeno-Associated Virus Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy, enabling the delivery of therapeutic DNA to target cells. However, the potential of AAV to deliver protein payloads has...

Enjoyed this paper on engineering AAVs to deliver proteins rather than DNA! Interestingly, the authors found that some proteins package spontaneously, while others need a nanobody inside of the AAV capsid - possibly due to varying subcellular localizations of proteins.

pubs.acs.org/doi/10.1021/...

Which programming language should I use? A guide for early-career researchers Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.

I write about marimo, and how to choose the right programming language for your research, today in @nature.com www.nature.com/articles/d41...