Puigserver Lab

Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice - Nature Communications Brown adipose tissue (BAT) plays a role in energy expenditure but its thermogenic activities differ between sexes. Here, the authors show that PGC-1α enhances mitochondrial function and BAT thermogene...

PGC-1α–mediated phospholipid synthesis plays a pivotal role in BAT thermogenesis in a sex-dependent manner in mice revealing a new therapeutic target for metabolic diseases in postmenopausal women. www.nature.com/articles/s41...

Thanks, Tom and Jonathan!
‪@danafarber.bsky.social‬
‪@harvardcellbio.bsky.social‬

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency.

t.co/m71gz29mUv

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

📢Article now online at Nature Cancer!

'Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia'

✏️By Young-Mee Kim, Jalees Rehman and colleagues

🔗 www.nature.com/articles/s43...

Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia - Nature Cancer Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

A vascular perspective on #cancer cachexia here restoring endothelial PGC1α activity preserved vascular density and muscle mass in tumor-bearing mice @natcancer.nature.com www.nature.com/articles/s43...

RBM43 controls PGC1α translation and a PGC1α-STING signaling axis Dumesic et al. identify RBM43 as an RNA-binding protein that governs mitochondrial biogenesis through suppression of PGC1α translation. RBM43 is induced by inflammatory signaling and controls a diabetogenic regulatory axis in adipocytes whereby decreased…

Online now: RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!

We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO

#CancerResearch #SyntheticLethality #Genomics #DepMap

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

@danafarber.bsky.social @harvardcellbio.bsky.social @danafarbernews.bsky.social

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity - Nature Cell Biology Latorre-Muro et al. show that the cytosolic chaperone PPID drives insertion of the mitochondrial import receptor TOM70 into the mitochondrial outer membrane, thereby regulating body temperature, gluco...

💫NEW by @ppuigserverb.bsky.social & co: the chaperone PPID drives insertion of the #mitochondria import receptor TOM70 into the mitochondrial outer membrane, regulating body temperature, glucose homeostasis and body weight in #obese mice.
👉https://rdcu.be/d8atv
www.nature.com/articles/s41...

We are looking for candidates with backgrounds in immunology, ideally with experience in multicolor FACS and single cell methods to complement our deep knowledge of cancer metabolism. More information about us can be found on our website: puigserver.dfci.harvard.edu (2/2)

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to pere_puigserver@dfci.harvard.edu. Please share! (1/2)

Very exciting findings @ppuigserverb.bsky.social connect mitochondrial ETC deficiencies with cancer cell immunogenicity expanding the repertoire of strategies to target tumor vulnerabilities

@ppuigserverb.bsky.social‬ @danafarber.bsky.social @harvardcellbio.bsky.social

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

Online now!

Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

👇
www.nature.com/articles/s43...

Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍

#mitochondria #cancer #keto

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity
www.nature.com/articles/s43...
@ppuigserverb.bsky.social @naturecancer.bsky.social
www.nature.com/articles/s43...

Thanks!

Thanks, HaGe!

Thanks Payam!

Thanks for the News!

Thanks Christian!

Fine-tuning tumor immunogenicity with mitochondrial complex I

Our views on a very cool paper from @ppuigserverb.bsky.social
we hope you like it!

www.nature.com/articles/s43...

Fine-tuning tumor immunogenicity with mitochondrial complex I - Nature Cancer Targeting mitochondrial metabolic activity is an active area of cancer research. A study now finds that a selective deficiency in mitochondrial complex I in melanoma cells increases mitochondrial acet...

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social
www.nature.com/articles/s43...

@danafarber.bsky.social @danafarbernews.bsky.social
@harvardcellbio.bsky.social

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

Thanks, HaGe!

Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders

New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social
rdcu.be/d5ptF