The Twinkle Factory

🔬🌈 first-ever application of #CATCHFIRE to force the tethering of #mitochondria to the microtubule motor KIF17

Découverte du rôle des mitochondries dans la différenciation des cellules en neurones Grâce à une expérience menée sur la moelle épinière d’embryons de poulet, des biologistes ont constaté lors de la division cellulaire un nombre moins élevé d’organites dans les cellules qui deviendron...

🔬🌈 Première application de #CATCHFIRE ! Dans Le Monde. Suite au papier dans Nature Communications de Benjamin Bunel, Xavier Morin, Evelyne Fischer et al. (@ibensens.bsky.social)

www.lemonde.fr/sciences/art...

We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social

#AuPROTAC

#TPD

🔬🌈 the latest of #CATCHFIRE in bioRxiv

🔬🌈 the authors: "...unique role of the TAD in STAT5
nuclear trafficking, providing new mechanistic insight and potential targets for therapeutic intervention in diseases such as myeloproliferative neoplasms and
leukemia"

doi.org/10.64898/2025.12.11.693681

🔬🌈 #CATCHFIRE now implemented in neurogenesis studies!

🔬🌈 Check www.nature.com/articles/s41467-025-66932-0

Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis - Nature Communications Bunel et al. show that mitochondria behave as asymmetric fate determinants in vertebrates in vivo. Forcing their unequal segregation during mitosis is sufficient to drive premature neural differentiat...

🔬🌈 Into #neurogenesis studies?

🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis

www.nature.com/articles/s41...

New biosensor for REDOX lovers! Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈!

@messenslab.bsky.social

🌈 #CATCHFIRE unexpectedly used to track protein excretion by B. subtilis

🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062

🌈 #CATCHFIRE now applied to force mitochondria displacement during mitosis and drive premature neuronal differentiation

🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2

A color-tailored fluorogenic sensor for hydrogen peroxide - Nature Chemical Biology Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable colors, to track very low peroxid...

🌈 into H2O2 sensing? Check this paper on HyPerFLEX, an upgrade of the famous Hyper sensor family, combined with #FAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 www.nature.com/articles/s41...

🌈 a thorough review on fluorescent biosensors. Thxs!
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)