Group Leader – Molecular Systems Biology Unit Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

30.07.2025 15:14 — 👍 72    🔁 78    💬 1    📌 1

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

30.07.2025 13:41 — 👍 192    🔁 226    💬 0    📌 9

2026 Canada Excellence Research Chair Opportunities | Research & Innovation

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

31.05.2025 12:46 — 👍 37    🔁 45    💬 1    📌 0

Safeguarding the future of biomedical science in the United States NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes Americ...

Safeguarding the future of biomedical science in the United States: Cell www.cell.com/cell/fulltex...

02.03.2025 16:05 — 👍 1    🔁 0    💬 0    📌 0

Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation CRISPR/Cas9 technologies provide unique capabilities for modeling disease and understanding gene-to-phenotype connections. In cultured cells, chemical-mediated control of Cas9 activity can limit off-t...

www.biorxiv.org/content/10.1...

28.12.2024 19:13 — 👍 2    🔁 0    💬 0    📌 0

Degron-modified Cas12a enhances single-cell CRISPR screening Single-cell CRISPR (Perturb-seq) screens have primarily relied on Cas9 whereas Cas12a, despite its unique effectiveness for multiplex guide expression, remains underexplored. This may be due to Cas12a...

Have you been interested combining Perturb-Seq screening with Cas12a’s unique capabilities for multiplexed guide RNA expression? Us too! So, we figured out some useful tricks to make that possible, which you can find in our new pre-print. Short thread below: www.biorxiv.org/content/10.1...

09.12.2024 13:05 — 👍 22    🔁 11    💬 2    📌 2

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

29.11.2024 16:17 — 👍 195    🔁 77    💬 12    📌 3

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

📢 Preprint! How does the environment of a father before conception influence offspring?

Even more, how do paternal genetics & ages interact with exposures to affect F1 outcome?

We tested this systematically, with intriguing findings & some cautionary tales🧵...

www.biorxiv.org/content/10.1...

26.11.2024 16:35 — 👍 108    🔁 47    💬 12    📌 7

‘DNA Typewriters’ Can Record a Cell’s History Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.

What if we could read the diary of a cell?

Researchers from around the world, including #SeaSynBio's @jshendure.bsky.social, share with @nytimes.com' @carlzimmer.bsky.social their vision for how an emerging suite of technologies could change how we study life.

🔗 www.nytimes.com/2024/11/25/s...

26.11.2024 22:13 — 👍 18    🔁 5    💬 0    📌 1

diagrams of gut-brain communication

Very good, concise summary of the gut-brain axis of communication and interoception
www.cell.com/current-biol... open-access

24.11.2024 20:41 — 👍 468    🔁 96    💬 10    📌 7