Martina Foglizzo

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...

We're looking for a new lecturer, here at the Department of Biochemistry in Dunedin, New Zealand. "Applications are invited in all areas of biochemistry, molecular genetics, and bioinformatics." otago.taleo.net/careersectio...

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1 Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk

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Delighted to see Jon Machin's lovely OMP folding and assembly work on the front cover of JMB (doi: 10.1016/j.jmb.2025.169346) and in this Faraday Discussion article (doi: 10.1039/d4fd00180). Congratulations on your great work Jonathan!

MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic ra…

Happy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports!

www.sciencedirect.com/science/arti...

Exciting work led by @nano-chalmers.bsky.social delivered in collaboration with @georgerheath.bsky.social introducing a rationally designed DNA origami system for the multiplexed detection of miRNA in crude RNA extracts via nanopore sensing.

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

💫NEW: @buszczaklab.bsky.social @jun-wu-lab.bsky.social & co use human #brain #organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired #ribosome production and protein synthesis, and delayed radial glial cell specification.
bit.ly/4lvVBBP

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌

www.cell.com/molecular-ce...

A rare job opportunity for a biochemist who wants to work in beautiful Dunedin.
Will suit someone who enjoys lab-based work.
otago.taleo.net/careersectio...

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.

It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.biochemistry.org/events-and-t...

Identification of RING E3 pseudoligases in the TRIM protein family Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

#TeamTomo is going to be all over chromatin structure and organization in the next years. Beautiful efforts like this are only the beginning! 🧪🧶🧬🔬

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Well done Alex! 🥳

New paper alert 🚨

We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.

Thrilled to see this finally out at @lsajournal.org .

www.life-science-alliance.org/content/8/6/...

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

It's finally out in @cp-molcell.bsky.social. Huge thanks to @leneyms.bsky.social and team Morris @themorrislab.bsky.social for getting this SUMO4 story over the finish line!

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair: Molecular Cell www.cell.com/molecular-ce...

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK-inhibitors availab...

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

Structure of human PINK1 at a mitochondrial TOM-VDAC array Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...

Structure of human PINK1 at a mitochondrial TOM-VDAC array | Science www.science.org/doi/10.1126/...

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social