Martina Foglizzo

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.

It’s too late on a Friday night for me to post sensibly about this work! But I’m super proud of Joanna’s determination to validate Parkin substrates and I love working with her robust and creative science!

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿

www.biochemistry.org/events-and-t...

Identification of RING E3 pseudoligases in the TRIM protein family Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

#TeamTomo is going to be all over chromatin structure and organization in the next years. Beautiful efforts like this are only the beginning! 🧪🧶🧬🔬

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

Well done Alex! 🥳

New paper alert 🚨

We determined the structure of phiCD508, a 225 nm tailed myovirus #phage infecting clinical strains of C. difficile, using #cryoEM.

Thrilled to see this finally out at @lsajournal.org .

www.life-science-alliance.org/content/8/6/...

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

It's finally out in @cp-molcell.bsky.social. Huge thanks to @leneyms.bsky.social and team Morris @themorrislab.bsky.social for getting this SUMO4 story over the finish line!

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair: Molecular Cell www.cell.com/molecular-ce...

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK-inhibitors availab...

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

Structure of human PINK1 at a mitochondrial TOM-VDAC array Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson’s Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determi...

Structure of human PINK1 at a mitochondrial TOM-VDAC array | Science www.science.org/doi/10.1126/...

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social

Congrats Peter @petermace.bsky.social and team - beautiful work! 🥳

Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!

Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9

The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...

Take a look at our new paper! We show that YbiO can achieve a conductance equivalent to MscL, the largest known gated ion channel. We also show the presence of several subconducting states. One state is consistent with a structure we determine using cryoEM.

www.cell.com/structure/fu...

Sophie Hesketh on LinkedIn: #opentowork Hi everyone! I'm actively seeking an academic or industrial position either back in the UK/Europe, or outside of the government in the US. I have strong…

Hi Folks!
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...

Animation: BRCA1-BARD1 interact with nucleosomes.

(1/2) Here’s how a tumour suppressor repairs DNA:

A group of researchers, including scientists from the School of Molecular and Cellular Biology, witnessed a protein complex called BRCA1-BARD1 reading specific signposts for DNA damage in intricate detail for the very first time.

#WorldCancerDay

Poster showing a kinase domain emerging from Lake Wakatipu, with a list of speakers

Exciting to open registration for the IUBMB Focussed Meeting on Emerging roles of (pseudo)kinases! Fantastic speakers in an unmatched location, lots of speaking slots available for ECRS.
Interested in kinases or pseudokinases? We would love to see you in Queenstown!

www.ivvy.com.au/event/IUBMB2...