Katarzyna Ciazynska

The mechanistic basis of cargo selection during Golgi maturation Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...

Another installment of the 'Returning home" series at NSMB.

This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw

Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...

This review on licensing origins of DNA replication is out in @natsmb.nature.com. Supp videos 1-4 are ABSOLUTELY required viewing! Make sure not to miss them!

We invite you all to read the editorial outlining a pilot which aims to improve reporting light microscopy in our and other journals

www.nature.com/articles/s41...

a picture of two pretzels, covered in salt, on a table. The images evokes RNA loops in splicing.

NSMB June issue - fresh from the oven!
www.nature.com/nsmb/volumes...

The cover features articles from Wang et al. and Ling et al. who report cryo-EM structures of naturally occurring circularly permuted group II introns, revealing mechanisms of branching, self-splicing and circular RNA formation.

Applications close this Friday, 20th June.

Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Job Title: Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Location: New York, Shanghai, Beijing, Madrid or Milan Closing date: June 20th About Springe...

So excited to share that we @natsmb.nature.com are hiring a new editor! If you are interested about working with an intelligent, compassionate and funny team helping scientists publish great research, please consider applying. Deadline June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

NSMB is hiring!

Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Job Title: Associate or Senior Editor (Nature Structural & Molecular Biology and Nature Communications) Location: New York, Shanghai, Beijing, Madrid or Milan Closing date: June 20th About Springe...

We are hiring a new editor! If you want to join the Nature Structural & Molecular Biology team and help publish exciting research, please apply. Deadline is June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

PhD students in STEM: Nature wants to hear from you Nature - Buried in lab work or drowning in data? Take a break and help shape the future of PhD education.

📢 Calling PhD students 📢 we want to hear from you!

Help shape the future of PhD education. Take our survey to tell us all about your experiences

https://go.nature.com/43WmN6V

It's difficult to express how incredibly proud I am of this Focus issue on vibrational microscopy!!! As many of you know, I'm a spectroscopy dork, and I love the rich information vibrational microscopy (Raman, IR) offers. These methods have come a long way. Please check out the issue to learn more!

Fondly reminiscing about the approx. eight weeks I spent as a tv review commissioner.

Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬

Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction.

Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪

It was a pleasure to invite and handle this Review! Give it a read if you're interested in COPII or the secretory pathway 😎

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.

Check it out here!
rdcu.be/eeY1J

#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

#ScientistAtWork photo competition A celebration of the striking and colourful work that scientists do around the world.

It’s time for Nature’s #ScientistAtWork photo competition, a celebration of the striking and colourful work that scientists do around the world! Readers are invited to share some of their favourite snaps from their working lives. Learn more below! #Academicsky 🧪

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Conference banner for Keystone symposia: Imaging biomolecules across scales: from atoms to tissues March 23-26 2025. Shows a ski lift and a mountain range in the background.

I will be heading over to Keystone 23-26 March to attend 'Imaging Biomolecules Across Scales: From Atoms to Tissues' conference, representing NSMB @naturesmb.bsky.social

Reach out if you want to talk!

Very exciting opportunity! Have a chat with @katherine-brown.bsky.social if you want to learn more 😎

Trump’s siege of science: how the first 30 days unfolded and what’s next The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.

The breakneck pace and devastating impact of the Trump administration’s policy changes has researchers shocked.

https://go.nature.com/3CMl75y

Want to build #scicomm skills and tell the public about science & how it works? (for any reason...)
There are paid(!) internships at @broadinstitute.org, @science.org, @nature.com, @thetransmitter.bsky.social, @sciam.bsky.social with applications due soon. Links in thread. Grad students eligible!🧬🧪

I am actively looking for a research scientist position or research administration role within the Raleigh-Durham (RDU) area! Please reach out if my background and skillset might fit your labs needs :-) Lots of experience with preclinical models, translational neuroscience, and behavioral analyses!

Nature News intern; Springer Nature Opening Doors Programme Nature News Intern, Springer Nature Opening Doors Programme London, UK — Hybrid Working Model Application deadline: 28th February 2025 About Springer Nature Group Springer Nature opens the doors to di...

We are hiring an intern in the UK news team at Nature - a fantastic opportunity for any budding science journo! 6 months of on-the-job training, London based but partly remote, pays living wage. Apply by 28 Feb: springernature.wd3.myworkdayjobs.com/de-DE/Spring...

Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.

Interested in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK
details+registration: forms.gle/FLDr3ZWtVGXs...
Hope to see you there!

📢 We are now on Bluesky ✨ ! With great optimism and excitement we bring you research published in our pages and look forward to connecting with our community here where the skies are blue. 🦋