James Nathan

Thanks Pari!

New study reveals key enzyme to control cellular energy production and immune function | Cambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID) Uncovering ABHD11 as a key metabolic regulator could lead to new treatments for cancer, autoimmune diseases, and metabolic disorders.

🧬 New in @natchembio.nature.com :

Researchers at #CITIID @cam.ac.uk & @ki.se identified #ABHD11 – a key enzyme that controls cellular energy production & immune response. Learn more: buff.ly/ZdOAdLe

@hudsonwilco.bsky.social @jamesnathanlab.bsky.social

Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...

Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

www.nature.com/articles/s41...

🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social

Thanks to all members of the Nathan lab and our wonderful collaborators. #hypoxia #metabolism.

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau ( VHL ) tumour suppressor gene. Here, we und...

Third - our work examining synthetic lethality with VHL in renal cancer, uncovering a role for CBFB as a suppressor of Type I interferon signalling. www.biorxiv.org/content/10.1...

ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism Glutarate is an intermediate of amino acid catabolism and an important metabolite for reprogramming T cell immunity, exerting its effects by inhibition of histone demethylase enzymes or through glutar...

Second - our work with Randall Johnson's group uncovering a novel role for how ABHD11 controls #lipoylation by acting as a lipoyl deglutarylating enzyme to regulate the TCA cycle. www.biorxiv.org/content/10.1...

A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway Hypoxia Inducible transcription Factors (HIFs) are central to the metazoan oxygen-sensing response. Under low oxygen conditions (hypoxia), HIFs are stabilised and govern an adaptive transcriptional pr...

Having just joined bsky, thought it would be good to share our latest review and a couple of recent preprints from the group. First our review on the roles of deubiquitinating enzymes in hypoxia responses. portlandpress.com/biochemsoctr...

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People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.