Tong Lan

Engineering a human-based translational activator for targeted protein expression restoration Abstract. Therapeutic modalities to programmably increase protein production are in critical need to address diseases caused by deficient gene expression v

Excited to share our new work in @narjournal.bsky.social ! We engineered a human-based translational activator that rescued phenotypes in a Dravet syndrome mouse model by boosting protein expression from haploinsufficient genes. A thread on targeting translation 🧵
academic.oup.com/nar/article/...

Does a cell’s gene expression always reflect its function? Transcriptionally similar neurons can be functionally diverse.

Evidence suggests that transcriptionally similar cells can be functionally diverse

go.nature.com/3N4lT2d

Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

International Day for the Elimination of Violence against Women | United Nations The International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...

Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...

Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress Inside-out (I-O) protein display, the non-canonical surface localization of intracellular proteins, represents an underexplored feature of tumor cell biology. Here, we map the molecular landscape and ...

Interesting work profiling surface proteins from the Kossiakoff lab U Chicago. Corroborates the concept of @oawlab.bsky.social on cancer specific csU5-snRNP200 and our work on csNPM1 but here with more than 500 (!) novel Fabs and 40 antibodies developed. Very cool www.biorxiv.org/content/10.1...

Proof-of-concept innate immune checkpoint inhibitor shows promise against solid tumors in rodents | Arc Institute Biochemist Lingyin Li has been pioneering a new direction for immunotherapy, searching for drugs that would turn these “cold” environments “hot”. Instead of stimulating T cells in the adaptive immune…

ENPP1 drug developed by Institute Scholar @lingyinli.bsky.social gains FDA approval for Phase I cancer clinical trials: arcinstitute.org/news/stf-162...

This paper is now online at @cp-cellrepmed.bsky.social! Congratulations to all the authors. Read the paper here: www.cell.com/cell-reports...

PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social

www.nature.com/articles/s41...

‘Every failed experiment is a chance to learn faster’ Stanford biochemist Lingyin Li’s lab is studying a tumor-fighting “miracle molecule” that could one day inform therapies for cancer, as well as autoimmune, neurodegenerative, and age-related diseases.

In the latest Research Matters feature, @lingyinli.bsky.social discusses her quest for more broadly efficacious cancer therapies and the importance of learning from failures.
news.stanford.edu/stories/2025...

Xujun is presenting in front of his slide on the molecular mechanism of STING signaling.

Xujun and Lingyin sharing a toast.

It's been a busy week for the Li lab! The 10th PhD in 10 years, @xujunc.bsky.social successfully defended his thesis! Congratulations, and keep an eye out for his work on new STING inhibitors and regulators!

Lingyin and Songnan are posing for pictures beside a cake

Songnan cutting her celebratory cake

The ninth PhD defense from the lab by @songnanwang.bsky.social, now forging ahead with her MD-PhD! Excited for great things from Songnan yet to come!

Call to arms by @lisamjarvis.bsky.social for biopharma to mobilize in support of the engines that power them - federally supported biomedical research and drug evaluation

🎉🎉🎉

When This Stanford Professor Got Cancer, He Decided to Teach a Class About It Dr. Bryant Lin, who teaches medicine at Stanford University, was given a terminal diagnosis. He wanted his students to understand the humanity at the core of medicine.

Wanted to share this story about my colleague Bryant Lin. We’re working together on bringing art and science together but his story runs much deeper. www.nytimes.com/2025/02/26/u...

Group photo of current lab members with Lingyin marked out with an arrow

We're excited to share that our fearless leader @lingyinli.bsky.social has been promoted to full Professor of Biochemistry! Here's to decades more of research in therapeutics harnessing the innate immunity!

Happy International Day of Women and Girls in Science! 🧪 Celebrating the brilliant minds, past and present, who have pushed boundaries and shaped our understanding of the world. Here’s to the next generation of scientists who will take us even further!

Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery.

TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.

1/n

Lingyin is on stage in front of a screen presenting her slides

The Li lab is at the Cell Symposium @cellpress.bsky.social! Lab leader @lingyinli.bsky.social presents the lab's work on new therapeutic modalities harnessing the STING pathway

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/

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