Sergey Melnikov

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

19.06.2025 07:31 — 👍 31    🔁 20    💬 0    📌 3

This was a collaborative effort with the omnipotent Stefan Pfeffer and @chillzaa.bsky.social people (e.g. @sophiekopetschke.bsky.social).

20.03.2025 22:05 — 👍 3    🔁 0    💬 0    📌 0

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...

20.03.2025 22:05 — 👍 45    🔁 23    💬 1    📌 2

Thrilled to share our recent discovery from the Agrawal and Ojha Labs: an Actinobacteria-specific ribosome hibernation factor bound to Mycobacterium tuberculosis ribosomes isolated from biofilms. www.biorxiv.org/content/10.1...
@cryoempapers.bsky.social @mycobacterium.bsky.social

02.12.2024 21:09 — 👍 12    🔁 9    💬 0    📌 0